Detailed information of TA system TA138302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 273489..274021
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: FQP84_RS01530
• Protein ID: WP_001103942.1
• Coordinates: 273489..273809 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: FQP84_RS01535
• Protein ID: WP_001058486.1
• Coordinates: 273812..274021 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS01500	268637..268978	-	342	WP_001190615.1	hypothetical protein	-
FQP84_RS01505	269495..270136	-	642	WP_001019764.1	hypothetical protein	-
FQP84_RS01510	270133..270417	-	285	WP_000998181.1	hypothetical protein	-
FQP84_RS01515	270419..270781	-	363	WP_001039168.1	hypothetical protein	-
FQP84_RS01520	271082..272539	-	1458	WP_000390455.1	virulence-associated E family protein	-
FQP84_RS01525	272556..273425	-	870	WP_031901882.1	primase alpha helix C-terminal domain-containing protein	-
FQP84_RS01530	273489..273809	-	321	WP_001103942.1	DUF1474 family protein	Toxin
FQP84_RS01535	273812..274021	-	210	WP_001058486.1	hypothetical protein	Antitoxin
FQP84_RS01540	274014..274160	-	147	WP_000784875.1	hypothetical protein	-
FQP84_RS01545	274172..274444	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
FQP84_RS01550	274437..274700	-	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
FQP84_RS01555	274893..275225	+	333	WP_031901881.1	helix-turn-helix transcriptional regulator	-
FQP84_RS01560	275237..275695	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
FQP84_RS01565	275712..276143	+	432	WP_001228759.1	hypothetical protein	-
FQP84_RS01570	276213..276941	+	729	WP_031901880.1	staphylococcal enterotoxin type Q	-
FQP84_RS01575	276965..277693	+	729	WP_000733775.1	staphylococcal enterotoxin type K	-
FQP84_RS01580	277782..279002	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk	263687..296951	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T138302 WP_001103942.1 NZ_CP043302:c273809-273489 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T138302 NZ_CP043302:c273809-273489 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT138302 WP_001058486.1 NZ_CP043302:c274021-273812 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT138302 NZ_CP057561:c982455-982403 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: Q93CD4