Detailed information of TA system TA138301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 33823..34620
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A6B0C7N0
• Locus tag: FQP84_RS00280
• Protein ID: WP_000525009.1
• Coordinates: 34159..34620 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: FQP84_RS00275
• Protein ID: WP_001260487.1
• Coordinates: 33823..34146 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS00225	28883..29311	-	429	WP_000934784.1	single-stranded DNA-binding protein	-
FQP84_RS00230	29311..29934	-	624	WP_000139720.1	DUF1071 domain-containing protein	-
FQP84_RS00235	29927..30148	-	222	WP_000815403.1	DUF2483 family protein	-
FQP84_RS00240	30158..30418	-	261	WP_000291089.1	DUF1108 family protein	-
FQP84_RS00245	30510..30671	-	162	WP_000066021.1	DUF1270 family protein	-
FQP84_RS00250	30851..31081	+	231	WP_000395455.1	hypothetical protein	-
FQP84_RS00255	31257..31997	-	741	WP_001606750.1	phage antirepressor KilAC domain-containing protein	-
FQP84_RS00260	31999..32184	-	186	WP_000933364.1	helix-turn-helix transcriptional regulator	-
FQP84_RS15610	32626..32796	+	171	WP_001280594.1	hypothetical protein	-
FQP84_RS15615	32757..32918	-	162	WP_001153176.1	hypothetical protein	-
FQP84_RS00265	32952..33398	-	447	WP_000435350.1	hypothetical protein	-
FQP84_RS00270	33411..33659	-	249	WP_000272858.1	helix-turn-helix domain-containing protein	-
FQP84_RS00275	33823..34146	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
FQP84_RS00280	34159..34620	+	462	WP_000525009.1	hypothetical protein	Toxin
FQP84_RS00285	34638..35141	+	504	WP_000825944.1	hypothetical protein	-
FQP84_RS00290	35385..36770	+	1386	WP_000861313.1	recombinase family protein	-
FQP84_RS00295	36887..37060	-	174	WP_000290472.1	50S ribosomal protein L32	-
FQP84_RS00305	37140..37697	-	558	WP_000872158.1	DUF177 domain-containing protein	-
FQP84_RS00310	37824..38963	+	1140	WP_000843611.1	nucleotidyltransferase	-
FQP84_RS00315	39025..39507	-	483	WP_000401377.1	pantetheine-phosphate adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	10..41932	41922

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18060.39 Da
• Isoelectric Point: 4.5941

>T138301 WP_000525009.1 NZ_CP043302:34159-34620 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T138301 NZ_CP057561:c679678-679469 [Escherichia fergusonii]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT138301 WP_001260487.1 NZ_CP043302:33823-34146 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT138301 NZ_CP057561:679670-679727 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: A0A6B0C7N0

Antitoxin

• AlphaFold DB: A0A0C2LD36