Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 5093287..5093813 | Replicon | chromosome |
| Accession | NZ_CP043295 | ||
| Organism | Escherichia coli strain WCHEC040047 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | FYK54_RS24525 | Protein ID | WP_000323025.1 |
| Coordinates | 5093526..5093813 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | FYK54_RS24520 | Protein ID | WP_000534858.1 |
| Coordinates | 5093287..5093526 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK54_RS24490 (5088549) | 5088549..5089163 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| FYK54_RS24495 (5089166) | 5089166..5090188 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| FYK54_RS24500 (5090693) | 5090693..5091715 | + | 1023 | Protein_4789 | ISNCY family transposase | - |
| FYK54_RS24505 (5091836) | 5091836..5091985 | + | 150 | WP_011443592.1 | protein YdfW | - |
| FYK54_RS24510 (5092422) | 5092422..5092754 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| FYK54_RS24515 (5092957) | 5092957..5093262 | - | 306 | WP_001326990.1 | protein YdfV | - |
| FYK54_RS24520 (5093287) | 5093287..5093526 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| FYK54_RS24525 (5093526) | 5093526..5093813 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| FYK54_RS24530 (5093885) | 5093885..5094040 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| FYK54_RS24535 (5094257) | 5094257..5094508 | + | 252 | WP_000980994.1 | protein Rem | - |
| FYK54_RS24540 (5094575) | 5094575..5094853 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| FYK54_RS24545 (5094855) | 5094855..5095904 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| FYK54_RS24550 (5095918) | 5095918..5096670 | + | 753 | WP_001047135.1 | antitermination protein | - |
| FYK54_RS24555 (5096948) | 5096948..5097037 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| FYK54_RS24560 (5097092) | 5097092..5097304 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| FYK54_RS24565 (5097605) | 5097605..5097820 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| FYK54_RS24570 (5098271) | 5098271..5098729 | + | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 5072156..5106153 | 33997 | |
| - | flank | IS/Tn | - | - | 5098271..5098729 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T138291 WP_000323025.1 NZ_CP043295:5093526-5093813 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T138291 NZ_CP057509:c1138185-1137967 [Citrobacter freundii]
ATGTCTGATAAACCATTAACTAAAACAGATTATTTGATGCGTCTTCGACGCTGCCAGACAATTGACACGCTCGAGCGCGT
TATTGAGAAAAATAAATATGAATTGTCCGACAATGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACGATGAATAAGCTGTACGACAAGATTCCAACTTCCGTTTGGAAATTTATTCGCTAA
ATGTCTGATAAACCATTAACTAAAACAGATTATTTGATGCGTCTTCGACGCTGCCAGACAATTGACACGCTCGAGCGCGT
TATTGAGAAAAATAAATATGAATTGTCCGACAATGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACGATGAATAAGCTGTACGACAAGATTCCAACTTCCGTTTGGAAATTTATTCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT138291 WP_000534858.1 NZ_CP043295:5093287-5093526 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT138291 NZ_CP043295:5093287-5093526 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|