138279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3558127..3558781 Replicon chromosome
Accession NZ_CP043295
Organism Escherichia coli strain WCHEC040047

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag FYK54_RS17065 Protein ID WP_000244781.1
Coordinates 3558374..3558781 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FYK54_RS17060 Protein ID WP_000354046.1
Coordinates 3558127..3558393 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK54_RS17040 (3554215) 3554215..3555648 - 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -
FYK54_RS17045 (3555693) 3555693..3556004 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
FYK54_RS17050 (3556168) 3556168..3556827 + 660 WP_000250269.1 hemolysin III family protein -
FYK54_RS17055 (3556904) 3556904..3557884 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
FYK54_RS17060 (3558127) 3558127..3558393 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FYK54_RS17065 (3558374) 3558374..3558781 + 408 WP_000244781.1 protein YgfX Toxin
FYK54_RS17070 (3558821) 3558821..3559342 - 522 WP_001521233.1 flavodoxin FldB -
FYK54_RS17075 (3559454) 3559454..3560350 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FYK54_RS17080 (3560375) 3560375..3561085 + 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FYK54_RS17085 (3561091) 3561091..3562824 + 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T138279 WP_000244781.1 NZ_CP043295:3558374-3558781 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T138279 NZ_CP057506:531520-531804 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACAGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTCGCGGTAGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT138279 WP_000354046.1 NZ_CP043295:3558127-3558393 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138279 NZ_CP043295:3558127-3558393 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References