Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 797157..797992 Replicon chromosome
Accession NZ_CP043284
Organism Escherichia coli strain WCHEC025985

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7A2ZCB4
Locus tag FYK42_RS03885 Protein ID WP_061157978.1
Coordinates 797157..797534 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag FYK42_RS03890 Protein ID WP_001285610.1
Coordinates 797624..797992 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK42_RS03850 (792634) 792634..792837 + 204 Protein_756 type II secretion system protein GspJ -
FYK42_RS03855 (792840) 792840..793817 + 978 WP_000633220.1 type II secretion system minor pseudopilin GspK -
FYK42_RS03860 (793814) 793814..794992 + 1179 WP_000094970.1 type II secretion system protein GspL -
FYK42_RS03865 (794994) 794994..795530 + 537 WP_000942786.1 GspM family type II secretion system protein YghD -
FYK42_RS03870 (795811) 795811..796653 - 843 WP_001280493.1 DUF4942 domain-containing protein -
FYK42_RS03875 (796738) 796738..796935 - 198 WP_085949090.1 DUF957 domain-containing protein -
FYK42_RS03880 (796963) 796963..797160 - 198 Protein_762 DUF5983 family protein -
FYK42_RS03885 (797157) 797157..797534 - 378 WP_061157978.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
FYK42_RS03890 (797624) 797624..797992 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FYK42_RS03895 (798072) 798072..798293 - 222 WP_000692350.1 DUF987 domain-containing protein -
FYK42_RS03900 (798380) 798380..798856 - 477 WP_123005181.1 RadC family protein -
FYK42_RS03905 (798872) 798872..799042 - 171 Protein_767 antirestriction protein -
FYK42_RS03910 (799044) 799044..800864 - 1821 Protein_768 AIDA repeat-containing protein -
FYK42_RS03915 (801236) 801236..802108 - 873 WP_021527212.1 GTPase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13911.90 Da        Isoelectric Point: 7.9085

>T138232 WP_061157978.1 NZ_CP043284:c797534-797157 [Escherichia coli]
MKTLPVLPGQAASSHPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T138232 NZ_CP043284:c797534-797157 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACACCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT138232 WP_001285610.1 NZ_CP043284:c797992-797624 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT138232 NZ_CP043284:c797992-797624 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7A2ZCB4


Antitoxin

Source ID Structure

References