Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4203153..4203748 Replicon chromosome
Accession NZ_CP043279
Organism Escherichia coli strain WCHEC025157

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag FYK41_RS20070 Protein ID WP_000239579.1
Coordinates 4203153..4203503 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag FYK41_RS20075 Protein ID WP_001223208.1
Coordinates 4203497..4203748 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK41_RS20050 (4198600) 4198600..4199624 - 1025 Protein_3944 ABC transporter permease -
FYK41_RS20055 (4199635) 4199635..4201137 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
FYK41_RS20060 (4201277) 4201277..4202233 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FYK41_RS20065 (4202543) 4202543..4203073 + 531 WP_000055072.1 inorganic diphosphatase -
FYK41_RS20070 (4203153) 4203153..4203503 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
FYK41_RS20075 (4203497) 4203497..4203748 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FYK41_RS20080 (4203960) 4203960..4204301 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FYK41_RS20085 (4204304) 4204304..4208083 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T138217 WP_000239579.1 NZ_CP043279:c4203503-4203153 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T138217 NZ_CP043279:c4203503-4203153 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT138217 WP_001223208.1 NZ_CP043279:c4203748-4203497 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT138217 NZ_CP057463:c1043246-1042995 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References