Detailed information of TA system TA138162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 74362..74897
• Replicon: plasmid p1RM9973
• Accession: NZ_CP043273
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FYK17_RS23175
• Protein ID: WP_059257247.1
• Coordinates: 74610..74897 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8H9KB11
• Locus tag: FYK17_RS23170
• Protein ID: WP_001132891.1
• Coordinates: 74362..74613 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS23155	69641..70618	-	978	WP_059276356.1	RepB family plasmid replication initiator protein	-
FYK17_RS23160	71710..72876	+	1167	WP_059278927.1	plasmid-partitioning protein SopA	-
FYK17_RS23165	72876..73847	+	972	WP_207610760.1	ParB/RepB/Spo0J family plasmid partition protein	-
FYK17_RS23170	74362..74613	+	252	WP_001132891.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FYK17_RS23175	74610..74897	+	288	WP_059257247.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYK17_RS23180	75034..75776	+	743	Protein_80	transposase	-
FYK17_RS23185	75909..76640	+	732	Protein_81	IS66 family transposase	-
FYK17_RS23190	76673..77320	-	648	Protein_82	transposase zinc-binding domain-containing protein	-
FYK17_RS23195	77330..77518	-	189	Protein_83	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..105082	105082

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11194.26 Da
• Isoelectric Point: 10.5832

>T138162 WP_059257247.1 NZ_CP043273:74610-74897 [Escherichia albertii]
MTYTVKFRDDALKEWMKLDKSIQQQFAKKLKKCSENPHIPSAKLRELKNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Nucleotide

• Length: 288 bp

>T138162 NZ_CP057331:245313-245594 [Klebsiella oxytoca]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9181.39 Da
• Isoelectric Point: 4.0780

>AT138162 WP_001132891.1 NZ_CP043273:74362-74613 [Escherichia albertii]
MPNIILSDTSASVSELKKNPMATVGAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT138162 NZ_CP057331:245072-245323 [Klebsiella oxytoca]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA