Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 72639..73240 Replicon plasmid p2RM9973
Accession NZ_CP043272
Organism Escherichia albertii strain RM9973

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag FYK17_RS22585 Protein ID WP_001216034.1
Coordinates 72639..73019 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag FYK17_RS22590 Protein ID WP_001190712.1
Coordinates 73019..73240 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK17_RS22560 68084..69568 - 1485 WP_207610728.1 terminase -
FYK17_RS22565 69568..70761 - 1194 WP_207610729.1 terminase -
FYK17_RS22570 70843..71295 - 453 WP_001326849.1 late promoter-activating protein -
FYK17_RS22575 71384..72427 - 1044 WP_207610730.1 DUF968 domain-containing protein -
FYK17_RS22580 72455..72634 - 180 WP_108444139.1 PdcA protein -
FYK17_RS22585 72639..73019 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FYK17_RS22590 73019..73240 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FYK17_RS22595 73313..73702 - 390 WP_000506730.1 DNA repair protein -
FYK17_RS22600 73877..74449 + 573 WP_108444140.1 DNA-binding protein -
FYK17_RS22605 74456..74707 - 252 WP_001286531.1 DNA polymerase III subunit theta -
FYK17_RS22610 75022..75300 - 279 WP_207610731.1 hypothetical protein -
FYK17_RS22615 75293..76000 - 708 WP_108444141.1 hypothetical protein -
FYK17_RS22620 76296..76601 - 306 WP_059331348.1 hypothetical protein -
FYK17_RS22625 76591..76977 - 387 WP_207610732.1 hypothetical protein -
FYK17_RS22630 76984..77277 - 294 WP_000269002.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102351 102351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T138155 WP_001216034.1 NZ_CP043272:c73019-72639 [Escherichia albertii]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T138155 NZ_CP057330:933604-934014 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGACAGGGGGAAATAAAGCTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGCCTGCGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT138155 WP_001190712.1 NZ_CP043272:c73240-73019 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT138155 NZ_CP043272:c73240-73019 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACTCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References