Detailed information of TA system TA138151

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4496253..4496956
• Replicon: chromosome
• Accession: NZ_CP043271
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: A0A8H9EW26
• Locus tag: FYK17_RS21395
• Protein ID: WP_059273492.1
• Coordinates: 4496615..4496956 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8H9EVZ8
• Locus tag: FYK17_RS21390
• Protein ID: WP_059273493.1
• Coordinates: 4496253..4496594 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS21365	4492217..4494292	-	2076	WP_059273495.1	AAA family ATPase	-
FYK17_RS21370	4494714..4494923	-	210	WP_059273523.1	AlpA family transcriptional regulator	-
FYK17_RS21375	4494978..4495217	+	240	Protein_4157	DUF932 domain-containing protein	-
FYK17_RS21380	4495248..4495688	+	441	WP_137653832.1	antirestriction protein	-
FYK17_RS21385	4495701..4496242	+	542	Protein_4159	DNA repair protein RadC	-
FYK17_RS21390	4496253..4496594	+	342	WP_059273493.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FYK17_RS21395	4496615..4496956	+	342	WP_059273492.1	TA system toxin CbtA family protein	Toxin
FYK17_RS21400	4497220..4498227	+	1008	WP_137653831.1	restriction endonuclease	-
FYK17_RS21405	4498544..4499005	+	462	Protein_4163	ATP-dependent helicase	-
FYK17_RS21410	4499399..4499956	+	558	WP_000955766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12778.74 Da
• Isoelectric Point: 8.0324

>T138151 WP_059273492.1 NZ_CP043271:4496615-4496956 [Escherichia albertii]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQTTGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T138151 NZ_CP057314:34675-35145 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCTGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12829.28 Da
• Isoelectric Point: 5.0609

>AT138151 WP_059273493.1 NZ_CP043271:4496253-4496594 [Escherichia albertii]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRY
AHCVTLYHNGFTCEADTLGSYGYVYSAVYPTQR

Nucleotide

• Length: 342 bp

>AT138151 NZ_CP057314:34235-34678 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA