Detailed information of TA system TA138149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4318085..4319783
• Replicon: chromosome
• Accession: NZ_CP043271
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A1X3K0J2
• Locus tag: FYK17_RS20540
• Protein ID: WP_000365813.1
• Coordinates: 4318085..4319014 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: FYK17_RS20545
• Protein ID: WP_024165421.1
• Coordinates: 4319001..4319783 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS20525	4313576..4314214	+	639	WP_001145629.1	DUF1076 domain-containing protein	-
FYK17_RS20530	4314506..4315870	+	1365	WP_059255581.1	EspK/GogB family type III secretion system effector	-
FYK17_RS20535	4317014..4317472	-	459	WP_000526135.1	IS200/IS605 family transposase	-
FYK17_RS20540	4318085..4319014	-	930	WP_000365813.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FYK17_RS20545	4319001..4319783	-	783	WP_024165421.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FYK17_RS20550	4319932..4320801	+	870	WP_207610353.1	hypothetical protein	-
FYK17_RS20555	4320842..4321633	+	792	WP_207610354.1	hypothetical protein	-
FYK17_RS20560	4321723..4321926	-	204	Protein_3999	DUF3732 domain-containing protein	-
FYK17_RS20565	4322021..4324252	-	2232	WP_207610355.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	espG / escE / cesAB / escK / escL / escR / escS / escT / escU / etgA / cesD / escC / sepD / escJ / escI / sepZ/espZ / cesL / escV / escN / escO / sepQ/escQ / espH / cesF / map / tir / cesT / eae / escD / sepL / espA / espD / espB / cesD2 / escF / escG / espF / espK	4276377..4321633	45256
	-	flank	IS/Tn	-	-	4317014..4317472	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (12-274)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (96-247)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35115.59 Da
• Isoelectric Point: 6.1446

>T138149 WP_000365813.1 NZ_CP043271:c4319014-4318085 [Escherichia albertii]
MDLRDSYARQVRLLMTVLPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADREADLAAINDALMRITESLNGR
AGITAIRQENKTDEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLVGHPRPIAELLAPNWDTPRIATLYAQEFSGMTQRETSLESLLSVTMLLPQAL
KSHLTDRDRQFLLSYKQNTPDWSLYRYPEIQHLPAIRWKLRNLAVLNDKNPAKFAAAVSKLEGVLEQYF

Nucleotide

• Length: 930 bp

>T138149 NZ_CP057313:c4745556-4744639 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCAGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29286.64 Da
• Isoelectric Point: 8.4386

>AT138149 WP_024165421.1 NZ_CP043271:c4319783-4319001 [Escherichia albertii]
MPNYLNWLMQNTLPGQVLLQSWLVRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRQQVWLALAAYVKLPGWFVTFEQSVTFVTLYTSGLTVDVIPFTTKLNIGDRQLVGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPGGVEDGSA

Nucleotide

• Length: 783 bp

>AT138149 NZ_CP043271:c4319783-4319001 [Escherichia albertii]
TTGCCAAACTATCTAAACTGGTTGATGCAGAACACCCTCCCCGGTCAGGTGTTGCTTCAGTCATGGCTCGTCCGCAATGG
CATAGATCGTAAGCTCTCTTATCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTTTACTGTCGGACGG
GCCGTGAGCCGGATTGGGTGGACGCGGTTTACTGCCTGCAAACGCAGTGGGAAAAACCGGTTCGCGTGGCAGGGCTGACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGCAGACAGCAGGTCTGGCTCGCGCTTGCGGCTTACGTCAA
ACTGCCGGGATGGTTTGTCACCTTTGAGCAATCCGTAACGTTTGTCACGCTGTATACCTCTGGCCTCACCGTCGATGTAA
TACCATTCACGACAAAACTGAACATCGGCGACCGACAGTTAGTGGGCAGTGTCCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATATCGTTCGAACACGCCGACGCTCTGTTTCAGGGAATGAATCTTCTCAGCCCGCGTAAATT
ACAAACACTGCTCTGCGCCAGCCATTCGGTTAAAACCAACCGGGTGATGCTCTATCTTGCCCGACGCAACGAGCATCCTT
ACTTTCAGTACCTCGATCAAAGCGGTATAGAAACAGGCACTGGAAAACGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCAGGAGGAGTCGAAGATGGATCTGCGTGA

Structures

Toxin

• AlphaFold DB: A0A1X3K0J2