Detailed information of TA system TA138129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 76090..76637
• Replicon: plasmid p3RM9974
• Accession: NZ_CP043268
• Organism: Escherichia albertii strain RM9974

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FYK18_RS24965
• Protein ID: WP_244442846.1
• Coordinates: 76090..76368 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: FYK18_RS24970
• Protein ID: WP_000079941.1
• Coordinates: 76368..76637 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK18_RS24940 (72717)	72717..73319	+	603	WP_000517695.1	ProQ/FINO family protein	-
FYK18_RS24945 (73375)	73375..73869	+	495	WP_001459505.1	hypothetical protein	-
FYK18_RS24950 (73869)	73869..74135	+	267	WP_000955263.1	hypothetical protein	-
FYK18_RS24955 (74612)	74612..75061	-	450	WP_001236003.1	hypothetical protein	-
FYK18_RS24960 (75202)	75202..76050	-	849	WP_001057991.1	3'-5' exonuclease	-
FYK18_RS24965 (76090)	76090..76368	-	279	WP_244442846.1	type II toxin-antitoxin system toxin YacB	Toxin
FYK18_RS24970 (76368)	76368..76637	-	270	WP_000079941.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
FYK18_RS24975 (77546)	77546..78577	-	1032	WP_000907873.1	plasmid replication initiator RepA	-
FYK18_RS24980 (79583)	79583..79813	+	231	WP_228772074.1	ash family protein	-
FYK18_RS24985 (79731)	79731..80018	+	288	WP_000074849.1	conjugal transfer protein TraA	-
FYK18_RS24990 (80460)	80460..80993	+	534	WP_001303319.1	transcription termination/antitermination NusG family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..96650	96650

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10761.43 Da
• Isoelectric Point: 9.7617

>T138129 WP_244442846.1 NZ_CP043268:c76368-76090 [Escherichia albertii]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T138129 NZ_CP057311:c2581565-2581458 [Escherichia fergusonii]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATCGCTGGCATTCTTGCCAGTTTGAT
CGTGAACTGGCTGAACAAGCGGAACTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT138129 WP_000079941.1 NZ_CP043268:c76637-76368 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT138129 NZ_CP043268:c76637-76368 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5