Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 4732..5254 | Replicon | plasmid p4RM9974 |
| Accession | NZ_CP043267 | ||
| Organism | Escherichia albertii strain RM9974 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D0QMR1 |
| Locus tag | FYK18_RS24420 | Protein ID | WP_000220561.1 |
| Coordinates | 4732..5013 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | FYK18_RS24425 | Protein ID | WP_000121743.1 |
| Coordinates | 5003..5254 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK18_RS24375 (FYK18_24680) | 1..348 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| FYK18_RS24380 (FYK18_24685) | 345..593 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | - |
| FYK18_RS24385 (FYK18_24690) | 899..1249 | - | 351 | WP_000854261.1 | hypothetical protein | - |
| FYK18_RS24390 (FYK18_24695) | 1341..1640 | - | 300 | WP_000650311.1 | hypothetical protein | - |
| FYK18_RS24395 (FYK18_24705) | 2094..2321 | - | 228 | WP_000801440.1 | hypothetical protein | - |
| FYK18_RS24400 (FYK18_24710) | 2308..2559 | - | 252 | WP_001230707.1 | hypothetical protein | - |
| FYK18_RS24405 (FYK18_24715) | 2556..3098 | - | 543 | WP_001083906.1 | hypothetical protein | - |
| FYK18_RS24410 (FYK18_24720) | 3203..3718 | - | 516 | WP_001025397.1 | J domain-containing protein | - |
| FYK18_RS24415 (FYK18_24730) | 4358..4708 | - | 351 | WP_000312755.1 | hypothetical protein | - |
| FYK18_RS24420 (FYK18_24735) | 4732..5013 | - | 282 | WP_000220561.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FYK18_RS24425 (FYK18_24740) | 5003..5254 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| FYK18_RS24430 (FYK18_24750) | 6620..7627 | + | 1008 | WP_000243325.1 | replication initiation protein | - |
| FYK18_RS24435 (FYK18_24755) | 7693..8097 | + | 405 | WP_000654312.1 | hypothetical protein | - |
| FYK18_RS24440 (FYK18_24760) | 8233..8760 | + | 528 | WP_265451116.1 | DUF2726 domain-containing protein | - |
| FYK18_RS24445 (FYK18_24775) | 9332..9583 | - | 252 | WP_265451117.1 | hypothetical protein | - |
| FYK18_RS24450 (FYK18_24780) | 9620..9922 | - | 303 | WP_001062963.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..27507 | 27507 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11023.86 Da Isoelectric Point: 10.5938
>T138124 WP_000220561.1 NZ_CP043267:c5013-4732 [Escherichia albertii]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR
Download Length: 282 bp
>T138124 NZ_CP043267:c5013-4732 [Escherichia albertii]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTTGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATATGCGCTGA
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTTGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATATGCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT138124 WP_000121743.1 NZ_CP043267:c5254-5003 [Escherichia albertii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT138124 NZ_CP057311:1588247-1588621 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I302 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |