Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1..593 Replicon plasmid p4RM9974
Accession NZ_CP043267
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag FYK18_RS24380 Protein ID WP_000520549.1
Coordinates 345..593 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag FYK18_RS24375 Protein ID WP_000681613.1
Coordinates 1..348 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS24375 (FYK18_24680) 1..348 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYK18_RS24380 (FYK18_24685) 345..593 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
FYK18_RS24385 (FYK18_24690) 899..1249 - 351 WP_000854261.1 hypothetical protein -
FYK18_RS24390 (FYK18_24695) 1341..1640 - 300 WP_000650311.1 hypothetical protein -
FYK18_RS24395 (FYK18_24705) 2094..2321 - 228 WP_000801440.1 hypothetical protein -
FYK18_RS24400 (FYK18_24710) 2308..2559 - 252 WP_001230707.1 hypothetical protein -
FYK18_RS24405 (FYK18_24715) 2556..3098 - 543 WP_001083906.1 hypothetical protein -
FYK18_RS24410 (FYK18_24720) 3203..3718 - 516 WP_001025397.1 J domain-containing protein -
FYK18_RS24415 (FYK18_24730) 4358..4708 - 351 WP_000312755.1 hypothetical protein -
FYK18_RS24420 (FYK18_24735) 4732..5013 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin -
FYK18_RS24425 (FYK18_24740) 5003..5254 - 252 WP_000121743.1 plasmid stabilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..27507 27507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T138122 WP_000520549.1 NZ_CP043267:c593-345 [Escherichia albertii]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T138122 NZ_CP057311:c1058670-1058416 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT138122 WP_000681613.1 NZ_CP043267:c348-1 [Escherichia albertii]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT138122 NZ_CP043267:c348-1 [Escherichia albertii]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGACTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References