Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3160084..3160735 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag FYK18_RS16015 Protein ID WP_000244763.1
Coordinates 3160084..3160488 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FYK18_RS16020 Protein ID WP_000354046.1
Coordinates 3160469..3160735 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS15995 (3156042) 3156042..3157775 - 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -
FYK18_RS16000 (3157781) 3157781..3158491 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FYK18_RS16005 (3158516) 3158516..3159412 - 897 WP_059221133.1 site-specific tyrosine recombinase XerD -
FYK18_RS16010 (3159524) 3159524..3160045 + 522 WP_059221135.1 flavodoxin FldB -
FYK18_RS16015 (3160084) 3160084..3160488 - 405 WP_000244763.1 protein YgfX Toxin
FYK18_RS16020 (3160469) 3160469..3160735 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FYK18_RS16025 (3160725) 3160725..3160955 - 231 WP_000181267.1 hypothetical protein -
FYK18_RS16030 (3160987) 3160987..3161967 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
FYK18_RS16035 (3162169) 3162169..3162828 - 660 WP_000250281.1 hemolysin III family protein -
FYK18_RS16040 (3162996) 3162996..3163307 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
FYK18_RS16045 (3163352) 3163352..3164785 + 1434 WP_059221179.1 6-phospho-beta-glucosidase BglA -
FYK18_RS16050 (3164832) 3164832..3165725 - 894 WP_059221140.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T138117 WP_000244763.1 NZ_CP043266:c3160488-3160084 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T138117 NZ_CP043266:c3160488-3160084 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT138117 WP_000354046.1 NZ_CP043266:c3160735-3160469 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138117 NZ_CP043266:c3160735-3160469 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References