Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1586206..1586810 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name doc Uniprot ID A0A8H9B4D1
Locus tag FYK18_RS08105 Protein ID WP_059222236.1
Coordinates 1586206..1586592 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag FYK18_RS08110 Protein ID WP_001195490.1
Coordinates 1586589..1586810 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS08085 (1581527) 1581527..1582687 - 1161 WP_265451084.1 anaerobic sulfatase maturase -
FYK18_RS08090 (1582741) 1582741..1584423 - 1683 WP_059218791.1 sulfatase -
FYK18_RS08095 (1585118) 1585118..1586023 + 906 WP_265450921.1 ESPR-type extended signal peptide-containing protein -
FYK18_RS08100 (1586038) 1586038..1586121 + 84 WP_265451085.1 autotransporter outer membrane beta-barrel domain-containing protein -
FYK18_RS08105 (1586206) 1586206..1586592 - 387 WP_059222236.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FYK18_RS08110 (1586589) 1586589..1586810 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FYK18_RS08115 (1587228) 1587228..1587986 + 759 WP_059220136.1 trans-aconitate 2-methyltransferase -
FYK18_RS08120 (1587990) 1587990..1588904 - 915 WP_024164792.1 bestrophin family protein -
FYK18_RS08125 (1589109) 1589109..1590560 - 1452 WP_059220135.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14475.47 Da        Isoelectric Point: 8.0833

>T138105 WP_059222236.1 NZ_CP043266:c1586592-1586206 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLADPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

>T138105 NZ_CP043266:c1586592-1586206 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGGC
CGACCCCGGCAGAGCACAGGCGCTGATTTATCGCGTGCAGAACCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT138105 WP_001195490.1 NZ_CP043266:c1586810-1586589 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp

>AT138105 NZ_CP057266:c224889-224621 [Escherichia fergusonii]
AAAGTCAGCGAAGGGAATTTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References