Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 505850..506468 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FYK18_RS02635 Protein ID WP_001280991.1
Coordinates 505850..506068 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag FYK18_RS02640 Protein ID WP_000344798.1
Coordinates 506094..506468 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS02600 (501139) 501139..501711 + 573 WP_000779847.1 YbaY family lipoprotein -
FYK18_RS02605 (501741) 501741..502052 - 312 WP_000409915.1 MGMT family protein -
FYK18_RS02615 (502433) 502433..502786 + 354 WP_000878151.1 DUF1428 family protein -
FYK18_RS02620 (502824) 502824..504374 - 1551 WP_001260378.1 EAL domain-containing protein -
FYK18_RS02625 (504538) 504538..505008 - 471 WP_000136188.1 YlaC family protein -
FYK18_RS02630 (505116) 505116..505673 - 558 WP_059221620.1 maltose O-acetyltransferase -
FYK18_RS02635 (505850) 505850..506068 - 219 WP_001280991.1 HHA domain-containing protein Toxin
FYK18_RS02640 (506094) 506094..506468 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
FYK18_RS02645 (507023) 507023..510172 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
FYK18_RS02650 (510195) 510195..511388 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T138103 WP_001280991.1 NZ_CP043266:c506068-505850 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T138103 NZ_CP043266:c506068-505850 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT138103 WP_000344798.1 NZ_CP043266:c506468-506094 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT138103 NZ_CP057258:4393797-4394075 [Citrobacter freundii]
ATGAATAAACTTACTCGGTACGATCCCGCAACTGCGCTGGTTGATGATGAAGAAATTGCCGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAGCGTACATTGCAAAAGCCCTGGGCGTGGTGGCTCGCGCTAAGGGAATGGCGAACATCGCGGCAG
AAACGGGATTATCCCGCGAACAACTTTATCGCTCTTTTAGTGAGAAAGGTAACCCAACGCTGAAAACTACGCTTGCAGTG
ATGAAGGCGCTCGGTATTGAATTGACACTTAAAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References