Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 117998..118533 Replicon plasmid p1RM9976
Accession NZ_CP043265
Organism Escherichia albertii strain RM9976

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FYK19_RS26065 Protein ID WP_059257247.1
Coordinates 118246..118533 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8H9KB11
Locus tag FYK19_RS26060 Protein ID WP_001132891.1
Coordinates 117998..118249 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK19_RS26045 (113326) 113326..114303 - 978 WP_000361611.1 RepB family plasmid replication initiator protein -
FYK19_RS26050 (115346) 115346..116512 + 1167 WP_059257249.1 plasmid-partitioning protein SopA -
FYK19_RS26055 (116512) 116512..117483 + 972 WP_262939934.1 ParB/RepB/Spo0J family plasmid partition protein -
FYK19_RS26060 (117998) 117998..118249 + 252 WP_001132891.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FYK19_RS26065 (118246) 118246..118533 + 288 WP_059257247.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYK19_RS26070 (118657) 118657..119564 + 908 Protein_121 transposase -
FYK19_RS26075 (120047) 120047..120466 + 420 WP_059257246.1 transposase -
FYK19_RS26080 (120463) 120463..120813 + 351 WP_206867285.1 IS66 family insertion sequence element accessory protein TnpB -
FYK19_RS26085 (120844) 120844..122400 + 1557 WP_265463403.1 IS66 family transposase -
FYK19_RS26090 (122855) 122855..123280 + 426 WP_262939963.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - cofA 1..200522 200522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11194.26 Da        Isoelectric Point: 10.5832

>T138096 WP_059257247.1 NZ_CP043265:118246-118533 [Escherichia albertii]
MTYTVKFRDDALKEWMKLDKSIQQQFAKKLKKCSENPHIPSAKLRELKNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T138096 NZ_CP043265:118246-118533 [Escherichia albertii]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAAGAATGGATGAAACTGGATAAATCCATTCAGCAACAGTTCGC
AAAAAAATTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGTGAACTAAAAAATTGCTACAAAATCA
AACTTCGTGCATCGGGTTTTCGTCTGGTCTATCAGGTTATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTTGCCAGCGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.39 Da        Isoelectric Point: 4.0780

>AT138096 WP_001132891.1 NZ_CP043265:117998-118249 [Escherichia albertii]
MPNIILSDTSASVSELKKNPMATVGAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT138096 NZ_CP057258:c311762-311466 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTACGTATAGAGAAAGGTGAAGAAACACCTAA
ACCTGAACATGTGCATACTTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCGGTTGGTGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAACCCACTGGAGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAACCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References