Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 43034..43559 Replicon plasmid p1RM9976
Accession NZ_CP043265
Organism Escherichia albertii strain RM9976

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag FYK19_RS25670 Protein ID WP_059257238.1
Coordinates 43254..43559 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag FYK19_RS25665 Protein ID WP_059257239.1
Coordinates 43034..43252 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK19_RS25640 (38079) 38079..38429 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
FYK19_RS25645 (38460) 38460..40073 + 1614 WP_000080193.1 IS66-like element ISEc23 family transposase -
FYK19_RS25650 (40343) 40343..40723 + 381 WP_024214822.1 hypothetical protein -
FYK19_RS25655 (40839) 40839..41132 + 294 WP_149012631.1 hypothetical protein -
FYK19_RS25660 (42182) 42182..42436 - 255 WP_059242592.1 hypothetical protein -
FYK19_RS25665 (43034) 43034..43252 + 219 WP_059257239.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FYK19_RS25670 (43254) 43254..43559 + 306 WP_059257238.1 type II toxin-antitoxin system toxin CcdB Toxin
FYK19_RS25675 (43560) 43560..44366 + 807 WP_262939960.1 site-specific integrase -
FYK19_RS25680 (44924) 44924..45512 + 589 Protein_43 replication initiation protein RepE -
FYK19_RS25685 (46477) 46477..46830 + 354 WP_000864812.1 colicin M immunity protein -
FYK19_RS25690 (46880) 46880..47694 - 815 Protein_45 lipid II-degrading bacteriocin colicin M -
FYK19_RS25695 (47938) 47938..48465 + 528 WP_016233052.1 colicin B immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - cofA 1..200522 200522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.51 Da        Isoelectric Point: 6.4674

>T138093 WP_059257238.1 NZ_CP043265:43254-43559 [Escherichia albertii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPISVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T138093 NZ_CP057256:c2509204-2509097 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8328.19 Da        Isoelectric Point: 4.5045

>AT138093 WP_059257239.1 NZ_CP043265:43034-43252 [Escherichia albertii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQAENQEGMAEVARFIDTNGSFADENRDW

Download         Length: 219 bp

>AT138093 NZ_CP043265:43034-43252 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCAGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCCAGGTTTATTGACACGAACGGCTCCTTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References