Detailed information of TA system TA138092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 13471..14018
• Replicon: plasmid p1RM9976
• Accession: NZ_CP043265
• Organism: Escherichia albertii strain RM9976

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FYK19_RS25540
• Protein ID: WP_262939943.1
• Coordinates: 13740..14018 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A828ANF7
• Locus tag: FYK19_RS25535
• Protein ID: WP_059272212.1
• Coordinates: 13471..13740 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK19_RS25510 (10058)	10058..10360	+	303	WP_072146426.1	DUF1778 domain-containing protein	-
FYK19_RS25515 (10351)	10351..10833	+	483	WP_059257273.1	GNAT family N-acetyltransferase	-
FYK19_RS25520 (11144)	11144..11398	+	255	WP_000083830.1	replication regulatory protein RepA	-
FYK19_RS25525 (11505)	11505..11682	+	178	Protein_12	protein CopA/IncA	-
FYK19_RS25530 (11701)	11701..12558	+	858	WP_265463468.1	incFII family plasmid replication initiator RepA	-
FYK19_RS25535 (13471)	13471..13740	+	270	WP_059272212.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
FYK19_RS25540 (13740)	13740..14018	+	279	WP_262939943.1	type II toxin-antitoxin system toxin YacB	Toxin
FYK19_RS25545 (14064)	14064..14617	+	554	Protein_16	3'-5' exonuclease	-
FYK19_RS25550 (14805)	14805..15992	-	1188	Protein_17	IS91 family transposase	-
FYK19_RS25555 (15992)	15992..16357	-	366	WP_262933613.1	hypothetical protein	-
FYK19_RS25560 (16447)	16447..16647	+	201	Protein_19	IS3 family transposase	-
FYK19_RS25565 (16974)	16974..17426	+	453	WP_262939939.1	hypothetical protein	-
FYK19_RS25570 (17427)	17427..18326	+	900	WP_052432376.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	cofA	1..200522	200522
	-	flank	IS/Tn	-	-	14805..15629	824

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10691.29 Da
• Isoelectric Point: 7.2749

>T138092 WP_262939943.1 NZ_CP043265:13740-14018 [Escherichia albertii]
MEIFWTILASQDRKCIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T138092 NZ_CP057256:c2508721-2508614 [Escherichia fergusonii]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATCGCTGGCATTCTTGCCAGTTTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10224.57 Da
• Isoelectric Point: 8.8735

>AT138092 WP_059272212.1 NZ_CP043265:13471-13740 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT138092 NZ_CP043265:13471-13740 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A828ANF7