Detailed information of TA system TA138082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 3857689..3858489
• Replicon: chromosome
• Accession: NZ_CP043262
• Organism: Escherichia albertii strain RM9976

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FYK19_RS19165
• Protein ID: WP_161537617.1
• Coordinates: 3857689..3858216 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FYK19_RS19170
• Protein ID: WP_001277104.1
• Coordinates: 3858223..3858489 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK19_RS19140 (3852764)	3852764..3853531	-	768	WP_044709901.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
FYK19_RS19145 (3853528)	3853528..3854805	-	1278	WP_161537618.1	branched chain amino acid ABC transporter permease LivM	-
FYK19_RS19150 (3854802)	3854802..3855728	-	927	WP_001295111.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
FYK19_RS19155 (3855776)	3855776..3856885	-	1110	WP_000827693.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
FYK19_RS19160 (3857309)	3857309..3857692	+	384	WP_113640799.1	aspartate 1-decarboxylase autocleavage activator PanM	-
FYK19_RS19165 (3857689)	3857689..3858216	-	528	WP_161537617.1	type II toxin-antitoxin system toxin acetyltransferase AtaT	Toxin
FYK19_RS19170 (3858223)	3858223..3858489	-	267	WP_001277104.1	type II toxin-antitoxin system antitoxin AtaR	Antitoxin
FYK19_RS19175 (3858639)	3858639..3859742	-	1104	WP_010319184.1	branched chain amino acid ABC transporter substrate-binding protein LivJ	-
FYK19_RS19180 (3860261)	3860261..3860662	+	402	WP_001071334.1	PTS sugar transporter subunit IIA	-
FYK19_RS19185 (3860669)	3860669..3861154	+	486	WP_000029259.1	PTS sugar transporter subunit IIB	-
FYK19_RS19190 (3861171)	3861171..3861917	+	747	WP_000151888.1	PTS sugar transporter subunit IIC	-
FYK19_RS19195 (3861910)	3861910..3862764	+	855	WP_000370584.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (90-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19648.52 Da
• Isoelectric Point: 6.9585

>T138082 WP_161537617.1 NZ_CP043262:c3858216-3857689 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQALGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T138082 NZ_CP057245:73457-73609 [Escherichia fergusonii]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGATTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9958.44 Da
• Isoelectric Point: 9.2519

>AT138082 WP_001277104.1 NZ_CP043262:c3858489-3858223 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNCASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Nucleotide

• Length: 267 bp

>AT138082 NZ_CP043262:c3858489-3858223 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACTGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA