Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3256787..3257438 Replicon chromosome
Accession NZ_CP043262
Organism Escherichia albertii strain RM9976

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag FYK19_RS16180 Protein ID WP_161537425.1
Coordinates 3256787..3257191 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FYK19_RS16185 Protein ID WP_000354046.1
Coordinates 3257172..3257438 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK19_RS16160 (3252745) 3252745..3254478 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
FYK19_RS16165 (3254484) 3254484..3255194 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FYK19_RS16170 (3255219) 3255219..3256115 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FYK19_RS16175 (3256227) 3256227..3256748 + 522 WP_161537424.1 flavodoxin FldB -
FYK19_RS16180 (3256787) 3256787..3257191 - 405 WP_161537425.1 protein YgfX Toxin
FYK19_RS16185 (3257172) 3257172..3257438 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FYK19_RS16190 (3257428) 3257428..3257658 - 231 WP_000181267.1 hypothetical protein -
FYK19_RS16195 (3257690) 3257690..3258670 + 981 WP_125060505.1 tRNA-modifying protein YgfZ -
FYK19_RS16200 (3259111) 3259111..3259770 - 660 WP_000250281.1 hemolysin III family protein -
FYK19_RS16205 (3259938) 3259938..3260249 - 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
FYK19_RS16210 (3260294) 3260294..3261727 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15819.70 Da        Isoelectric Point: 10.7510

>T138081 WP_161537425.1 NZ_CP043262:c3257191-3256787 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T138081 NZ_CP043262:c3257191-3256787 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGTTGGCAGGGGCAG
GAGTGGAGCATCGTCAGTGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT138081 WP_000354046.1 NZ_CP043262:c3257438-3257172 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138081 NZ_CP057245:31012-31356 [Escherichia fergusonii]
ATGGCTACTCAAATTTTAAATAGTGCAGAAGTGTCACTGCGTGCAGAGTCACGACTTACTGAACGCAGTCAGACGACGAT
CCCGGCAGTAATACGCGATGCTTTGCATCTCAAGCCCGGTGAGTATATTCATTACACTTTACTTGCAGGTGGTAAGGTCA
TCATGTCACGACAGAATGAAGAACAGGACGACCCTGTGATTTCGCAGTTTTTGACTTTTCTTGAAAACGACATGAAAAAG
AACCCACAGAAGATTGCTCCAGTTCCGACAATGTTCTGGGAAAGCATGAAAGCATTAACTGCCGGAATTAATGTTGATTT
AGACGCACCACTTACCGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References