Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2358927..2359531 Replicon chromosome
Accession NZ_CP043262
Organism Escherichia albertii strain RM9976

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag FYK19_RS11615 Protein ID WP_000638401.1
Coordinates 2359145..2359531 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag FYK19_RS11610 Protein ID WP_001195490.1
Coordinates 2358927..2359148 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK19_RS11590 (2354114) 2354114..2355382 + 1269 WP_265463177.1 phage coat protein -
FYK19_RS11595 (2355489) 2355489..2355743 + 255 WP_262939711.1 hypothetical protein -
FYK19_RS11600 (2355751) 2355751..2357007 + 1257 WP_262939712.1 zonular occludens toxin domain-containing protein -
FYK19_RS11605 (2357017) 2357017..2358237 + 1221 WP_123003935.1 type II secretion system protein GspD -
FYK19_RS11610 (2358927) 2358927..2359148 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FYK19_RS11615 (2359145) 2359145..2359531 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FYK19_RS11620 (2359611) 2359611..2359841 - 231 Protein_2271 autotransporter outer membrane beta-barrel domain-containing protein -
FYK19_RS11625 (2359852) 2359852..2363979 - 4128 WP_262939714.1 ESPR-type extended signal peptide-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2342683..2359531 16848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T138075 WP_000638401.1 NZ_CP043262:2359145-2359531 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

>T138075 NZ_CP057244:c70550-70344 [Escherichia fergusonii]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTTACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT138075 WP_001195490.1 NZ_CP043262:2358927-2359148 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp

>AT138075 NZ_CP043262:2358927-2359148 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References