Detailed information of TA system TA138065

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 945469..946301
• Replicon: chromosome
• Accession: NZ_CP043262
• Organism: Escherichia albertii strain RM9976

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FYK19_RS04575
• Protein ID: WP_265462727.1
• Coordinates: 945927..946301 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: F4TJC4
• Locus tag: FYK19_RS04570
• Protein ID: WP_001285579.1
• Coordinates: 945469..945837 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK19_RS04550 (943219)	943219..944036	+	818	Protein_883	DUF932 domain-containing protein	-
FYK19_RS04555 (944128)	944128..944613	+	486	WP_000206669.1	antirestriction protein	-
FYK19_RS04560 (944629)	944629..945105	+	477	WP_001186706.1	RadC family protein	-
FYK19_RS04565 (945168)	945168..945389	+	222	WP_000692345.1	DUF987 domain-containing protein	-
FYK19_RS04570 (945469)	945469..945837	+	369	WP_001285579.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FYK19_RS04575 (945927)	945927..946301	+	375	WP_265462727.1	TA system toxin CbtA family protein	Toxin
FYK19_RS04580 (946298)	946298..946789	+	492	WP_000976868.1	DUF5983 family protein	-
FYK19_RS04585 (946801)	946801..946998	+	198	WP_000772030.1	DUF957 domain-containing protein	-
FYK19_RS04590 (947095)	947095..947937	+	843	WP_001290259.1	DUF4942 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14029.84 Da
• Isoelectric Point: 7.2920

>T138065 WP_265462727.1 NZ_CP043262:945927-946301 [Escherichia albertii]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITQGKHPEAK

Nucleotide

• Length: 375 bp

>T138065 NZ_CP057243:1998214-1998317 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13580.39 Da
• Isoelectric Point: 7.3223

>AT138065 WP_001285579.1 NZ_CP043262:945469-945837 [Escherichia albertii]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Nucleotide

• Length: 369 bp

>AT138065 NZ_CP043262:945469-945837 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAAAGGGCTGACCTGCAAAGCCGACACCCTCGGTAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z8DWX2