Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/DUF1778(antitoxin) |
| Location | 80965..81740 | Replicon | plasmid p1RM10507 |
| Accession | NZ_CP043261 | ||
| Organism | Escherichia albertii strain RM10507 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A828GRZ2 |
| Locus tag | FYK20_RS25930 | Protein ID | WP_001569490.1 |
| Coordinates | 80965..81447 (-) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | - |
| Locus tag | FYK20_RS25935 | Protein ID | WP_170978511.1 |
| Coordinates | 81438..81740 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK20_RS25895 (76065) | 76065..76852 | - | 788 | Protein_65 | transposase | - |
| FYK20_RS25900 (77044) | 77044..77325 | - | 282 | WP_000780222.1 | helix-turn-helix transcriptional regulator | - |
| FYK20_RS25905 (77306) | 77306..77635 | - | 330 | WP_086258293.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FYK20_RS25910 (78576) | 78576..79598 | - | 1023 | WP_265464769.1 | plasmid replication initiator RepA | - |
| FYK20_RS25915 (79588) | 79588..80121 | - | 534 | WP_265464770.1 | plasmid replication initiator RepA | - |
| FYK20_RS25920 (80114) | 80114..80188 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| FYK20_RS25925 (80426) | 80426..80680 | - | 255 | WP_000083846.1 | replication regulatory protein RepA | - |
| FYK20_RS25930 (80965) | 80965..81447 | - | 483 | WP_001569490.1 | GNAT family N-acetyltransferase | Toxin |
| FYK20_RS25935 (81438) | 81438..81740 | - | 303 | WP_170978511.1 | DUF1778 domain-containing protein | Antitoxin |
| FYK20_RS25940 (82062) | 82062..82211 | - | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| FYK20_RS25945 (82275) | 82275..83348 | + | 1074 | WP_099588292.1 | integrase core domain-containing protein | - |
| - (83357) | 83357..83557 | - | 201 | NuclAT_0 | - | - |
| - (83357) | 83357..83557 | - | 201 | NuclAT_0 | - | - |
| - (83357) | 83357..83557 | - | 201 | NuclAT_0 | - | - |
| - (83357) | 83357..83557 | - | 201 | NuclAT_0 | - | - |
| FYK20_RS25950 (83582) | 83582..84091 | - | 510 | WP_113650905.1 | hypothetical protein | - |
| FYK20_RS25955 (84091) | 84091..84810 | - | 720 | WP_265464771.1 | plasmid SOS inhibition protein A | - |
| FYK20_RS25960 (84864) | 84864..85241 | - | 378 | WP_113650848.1 | conjugation system SOS inhibitor PsiB | - |
| FYK20_RS25965 (85231) | 85231..85577 | - | 347 | Protein_79 | hypothetical protein | - |
| FYK20_RS25970 (85558) | 85558..85772 | + | 215 | Protein_80 | peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | vat | 1..102034 | 102034 | |
| - | flank | IS/Tn | - | - | 82275..83348 | 1073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17742.48 Da Isoelectric Point: 6.5977
>T138062 WP_001569490.1 NZ_CP043261:c81447-80965 [Escherichia albertii]
MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQILNASRTFVICLEDTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVANLAEQVGIKAVMVHAIDDDARVFYEHFGFVQSVVAPETLFYKI
MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQILNASRTFVICLEDTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVANLAEQVGIKAVMVHAIDDDARVFYEHFGFVQSVVAPETLFYKI
Download Length: 483 bp
>T138062 NZ_CP043261:c81447-80965 [Escherichia albertii]
ATGGAAATAAATGTCACCGCGCCGGCATTGCTGACAGATGAGCATATACTTCAGCCATTTGACTGTGGGAATGAGGTGTT
AAGTAACTGGTTGCGTGGTCGGGCTATGAAAAACCAGATACTCAATGCTTCCCGCACATTCGTCATTTGTCTGGAGGATA
CTTTACGTGTTGTGGGGTATTACTCATTAGCTACTGGTTCTGTCACACATGCCGAGCTTGGGCGCAGTTTGCGCCATAAT
ATGCCCAATCCTGTACCTGTTGTTCTTTTAGGGCGTCTGGCTGTCGATGTTTGTACTCAGGGACATGGTTTCGGTAAATG
GCTGCTGAGTGATGCCATTCATCGGGTTGCCAATCTGGCTGAACAGGTTGGCATTAAGGCTGTTATGGTTCATGCAATTG
ATGATGACGCCAGAGTTTTTTATGAGCATTTTGGTTTTGTTCAGTCAGTTGTGGCACCTGAGACCTTGTTTTATAAAATT
TGA
ATGGAAATAAATGTCACCGCGCCGGCATTGCTGACAGATGAGCATATACTTCAGCCATTTGACTGTGGGAATGAGGTGTT
AAGTAACTGGTTGCGTGGTCGGGCTATGAAAAACCAGATACTCAATGCTTCCCGCACATTCGTCATTTGTCTGGAGGATA
CTTTACGTGTTGTGGGGTATTACTCATTAGCTACTGGTTCTGTCACACATGCCGAGCTTGGGCGCAGTTTGCGCCATAAT
ATGCCCAATCCTGTACCTGTTGTTCTTTTAGGGCGTCTGGCTGTCGATGTTTGTACTCAGGGACATGGTTTCGGTAAATG
GCTGCTGAGTGATGCCATTCATCGGGTTGCCAATCTGGCTGAACAGGTTGGCATTAAGGCTGTTATGGTTCATGCAATTG
ATGATGACGCCAGAGTTTTTTATGAGCATTTTGGTTTTGTTCAGTCAGTTGTGGCACCTGAGACCTTGTTTTATAAAATT
TGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11629.22 Da Isoelectric Point: 4.4569
>AT138062 WP_170978511.1 NZ_CP043261:c81740-81438 [Escherichia albertii]
MEVVMPTTANIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK
MEVVMPTTANIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK
Download Length: 303 bp
>AT138062 NZ_CP043261:c81740-81438 [Escherichia albertii]
ATGGAGGTTGTTATGCCTACTACTGCAAACATCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACGGATGA
GGAACGAGCCGTTATTGATTATGCCGCTAGCCTGGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATCATCTTGGATCAACGTTTATTTGTGCTGGATGATGAATGTTATGATTCATTTATTACGCAACTGGAA
GCTCCTGTACAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA
ATGGAGGTTGTTATGCCTACTACTGCAAACATCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACGGATGA
GGAACGAGCCGTTATTGATTATGCCGCTAGCCTGGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATCATCTTGGATCAACGTTTATTTGTGCTGGATGATGAATGTTATGATTCATTTATTACGCAACTGGAA
GCTCCTGTACAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|