Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 65007..65608 Replicon plasmid p2RM10507
Accession NZ_CP043260
Organism Escherichia albertii strain RM10507

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FYK20_RS25405 Protein ID WP_113650805.1
Coordinates 65228..65608 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag FYK20_RS25400 Protein ID WP_001190712.1
Coordinates 65007..65228 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK20_RS25390 (FYK20_25780) 62087..63271 - 1185 WP_159186965.1 restriction endonuclease subunit S -
FYK20_RS25395 (FYK20_25785) 63268..64824 - 1557 WP_265464724.1 type I restriction-modification system subunit M -
FYK20_RS25400 (FYK20_25790) 65007..65228 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FYK20_RS25405 (FYK20_25795) 65228..65608 + 381 WP_113650805.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FYK20_RS25410 (FYK20_25800) 65613..65792 + 180 WP_000113018.1 hypothetical protein -
FYK20_RS25415 (FYK20_25805) 65820..66863 + 1044 WP_265464725.1 DUF968 domain-containing protein -
FYK20_RS25420 (FYK20_25810) 66952..67404 + 453 WP_001326849.1 late promoter-activating protein -
FYK20_RS25425 (FYK20_25815) 67491..68684 + 1194 WP_000219618.1 hypothetical protein -
FYK20_RS25430 (FYK20_25820) 68684..70168 + 1485 WP_124866780.1 terminase -
FYK20_RS25435 (FYK20_25825) 70390..70509 + 120 WP_071527722.1 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99002 99002


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13664.39 Da        Isoelectric Point: 5.1514

>T138060 WP_113650805.1 NZ_CP043260:65228-65608 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVYSVADTLRRLYGSAE

Download         Length: 381 bp

>T138060 NZ_CP057243:c715014-714805 [Escherichia fergusonii]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT138060 WP_001190712.1 NZ_CP043260:65007-65228 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT138060 NZ_CP057243:715006-715063 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References