Detailed information of TA system TA138057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4913779..4914355
• Replicon: chromosome
• Accession: NZ_CP043258
• Organism: Escherichia albertii strain RM10507

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: FYK20_RS24210
• Protein ID: WP_024164652.1
• Coordinates: 4913779..4914066 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: FYK20_RS24215
• Protein ID: WP_000063163.1
• Coordinates: 4914053..4914355 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK20_RS24195 (4909373)	4909373..4910743	-	1371	WP_000527982.1	restriction endonuclease subunit S	-
FYK20_RS24200 (4910733)	4910733..4912352	-	1620	WP_265464089.1	class I SAM-dependent DNA methyltransferase	-
FYK20_RS24205 (4912416)	4912416..4913582	-	1167	WP_000800832.1	restriction endonuclease	-
FYK20_RS24210 (4913779)	4913779..4914066	+	288	WP_024164652.1	BrnT family toxin	Toxin
FYK20_RS24215 (4914053)	4914053..4914355	+	303	WP_000063163.1	BrnA antitoxin family protein	Antitoxin
FYK20_RS24220 (4914389)	4914389..4915345	-	957	WP_085455854.1	GTPase	-
FYK20_RS24225 (4915356)	4915356..4915559	-	204	WP_000467859.1	YbdD/YjiX family protein	-
FYK20_RS24230 (4915679)	4915679..4917829	-	2151	WP_265464090.1	pyruvate/proton symporter BtsT	-
FYK20_RS24235 (4918329)	4918329..4918647	+	319	Protein_4717	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11128.57 Da
• Isoelectric Point: 6.9903

>T138057 WP_024164652.1 NZ_CP043258:4913779-4914066 [Escherichia albertii]
MPMEFEWDANKAKSNQVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG

Nucleotide

• Length: 288 bp

>T138057 NZ_CP043258:4913779-4914066 [Escherichia albertii]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCAGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTACACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11541.03 Da
• Isoelectric Point: 9.8217

>AT138057 WP_000063163.1 NZ_CP043258:4914053-4914355 [Escherichia albertii]
MSMVKHKRGTSSTLDVQREAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT138057 NZ_CP043258:4914053-4914355 [Escherichia albertii]
ATGAGCATGGTTAAACATAAACGAGGGACTTCCTCTACACTCGATGTGCAGCGTGAGGCCGAACTGAAGGCGCTGGCGAA
TAAGTCCGACGAGGATATTGATTACAGCGATATTCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCAGGCAAAGGT
TATCAGACTCGCCTGAACGCAATTTTACGTGAAGCGATGTTGCGCGATCAGAACAAAAAATAA