Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1866070..1866541 | Replicon | chromosome |
| Accession | NZ_CP043258 | ||
| Organism | Escherichia albertii strain RM10507 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | FYK20_RS09255 | Protein ID | WP_001303511.1 |
| Coordinates | 1866263..1866541 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | FYK20_RS09250 | Protein ID | WP_001302048.1 |
| Coordinates | 1866070..1866261 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK20_RS09200 (1861184) | 1861184..1861339 | - | 156 | WP_113649980.1 | type I toxin-antitoxin system toxin HokD | - |
| FYK20_RS09205 (1862070) | 1862070..1862396 | - | 327 | Protein_1798 | hypothetical protein | - |
| FYK20_RS09210 (1862393) | 1862393..1862569 | - | 177 | WP_000753060.1 | hypothetical protein | - |
| FYK20_RS09215 (1862562) | 1862562..1862744 | - | 183 | WP_059278956.1 | hypothetical protein | - |
| FYK20_RS09220 (1862838) | 1862838..1863194 | - | 357 | WP_059278958.1 | hypothetical protein | - |
| FYK20_RS09225 (1863252) | 1863252..1863673 | - | 422 | Protein_1802 | DUF977 family protein | - |
| FYK20_RS09230 (1863714) | 1863714..1864784 | - | 1071 | WP_059278957.1 | hypothetical protein | - |
| FYK20_RS09235 (1864856) | 1864856..1865281 | - | 426 | WP_001700667.1 | toxin YdaT family protein | - |
| FYK20_RS09240 (1865278) | 1865278..1865580 | - | 303 | WP_000172735.1 | transcriptional regulator | - |
| FYK20_RS09245 (1865678) | 1865678..1866049 | + | 372 | WP_122985828.1 | hypothetical protein | - |
| FYK20_RS09250 (1866070) | 1866070..1866261 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| FYK20_RS09255 (1866263) | 1866263..1866541 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FYK20_RS09260 (1866834) | 1866834..1866989 | + | 156 | WP_072248456.1 | DUF1391 family protein | - |
| FYK20_RS09265 (1866991) | 1866991..1867119 | + | 129 | WP_000344961.1 | protein YdfB | - |
| FYK20_RS09270 (1867149) | 1867149..1867367 | + | 219 | WP_001171923.1 | protein YdfC | - |
| FYK20_RS09275 (1867933) | 1867933..1868121 | + | 189 | WP_000449200.1 | cell division inhibition protein DicB | - |
| FYK20_RS09280 (1868118) | 1868118..1868309 | + | 192 | WP_001090221.1 | DUF1482 family protein | - |
| FYK20_RS09285 (1868402) | 1868402..1870873 | + | 2472 | WP_125295762.1 | exonuclease | - |
| FYK20_RS09290 (1870935) | 1870935..1871204 | + | 270 | WP_059274360.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espM2 | 1831518..1898238 | 66720 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T138042 WP_001303511.1 NZ_CP043258:1866263-1866541 [Escherichia albertii]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T138042 NZ_CP043258:1866263-1866541 [Escherichia albertii]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT138042 WP_001302048.1 NZ_CP043258:1866070-1866261 [Escherichia albertii]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT138042 NZ_CP057238:c1053392-1053138 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|