Detailed information of TA system TA138041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 1636752..1637347
• Replicon: chromosome
• Accession: NZ_CP043258
• Organism: Escherichia albertii strain RM10507

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FYK20_RS08035
• Protein ID: WP_265464410.1
• Coordinates: 1636752..1637129 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: B1ELZ9
• Locus tag: FYK20_RS08040
• Protein ID: WP_001195490.1
• Coordinates: 1637126..1637347 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK20_RS08025 (1633073)	1633073..1635823	+	2751	WP_265464409.1	ESPR-type extended signal peptide-containing protein	-
FYK20_RS08030 (1635813)	1635813..1636748	+	936	Protein_1566	autotransporter outer membrane beta-barrel domain-containing protein	-
FYK20_RS08035 (1636752)	1636752..1637129	-	378	WP_265464410.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FYK20_RS08040 (1637126)	1637126..1637347	-	222	WP_001195490.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FYK20_RS08045 (1637765)	1637765..1638523	+	759	WP_265464411.1	trans-aconitate 2-methyltransferase	-
FYK20_RS08050 (1638527)	1638527..1639441	-	915	WP_059256819.1	bestrophin family protein	-
FYK20_RS08055 (1639646)	1639646..1641097	-	1452	WP_265464412.1	tagaturonate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-116)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14261.24 Da
• Isoelectric Point: 6.8712

>T138041 WP_265464410.1 NZ_CP043258:c1637129-1636752 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLAQCLRERVDE

Nucleotide

• Length: 378 bp

>T138041 NZ_CP043258:c1637129-1636752 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACTTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCAATGTTTACGTGAACGAGTGGATGAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8067.96 Da
• Isoelectric Point: 4.6816

>AT138041 WP_001195490.1 NZ_CP043258:c1637347-1637126 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Nucleotide

• Length: 222 bp

>AT138041 NZ_CP057238:c1053640-1053389 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACTGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2S6PD20