Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 480931..481549 Replicon chromosome
Accession NZ_CP043258
Organism Escherichia albertii strain RM10507

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FYK20_RS02305 Protein ID WP_001280991.1
Coordinates 480931..481149 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X3JU63
Locus tag FYK20_RS02310 Protein ID WP_054411423.1
Coordinates 481175..481549 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK20_RS02270 (476206) 476206..476793 + 588 WP_265464196.1 YbaY family lipoprotein -
FYK20_RS02275 (476823) 476823..477134 - 312 WP_265464197.1 MGMT family protein -
FYK20_RS02285 (477515) 477515..477868 + 354 WP_265464198.1 DUF1428 family protein -
FYK20_RS02290 (477906) 477906..479456 - 1551 WP_001260378.1 EAL domain-containing protein -
FYK20_RS02295 (479620) 479620..480090 - 471 WP_000136188.1 YlaC family protein -
FYK20_RS02300 (480197) 480197..480754 - 558 WP_265464199.1 maltose O-acetyltransferase -
FYK20_RS02305 (480931) 480931..481149 - 219 WP_001280991.1 HHA domain-containing protein Toxin
FYK20_RS02310 (481175) 481175..481549 - 375 WP_054411423.1 Hha toxicity modulator TomB Antitoxin
FYK20_RS02315 (482104) 482104..485253 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
FYK20_RS02320 (485276) 485276..486469 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T138039 WP_001280991.1 NZ_CP043258:c481149-480931 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T138039 NZ_CP057231:c31062-30781 [Escherichia fergusonii]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14485.33 Da        Isoelectric Point: 4.8989

>AT138039 WP_054411423.1 NZ_CP043258:c481549-481175 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQVDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT138039 NZ_CP057231:c31303-31052 [Escherichia fergusonii]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A1X3JU63

References