Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 63350..63897 Replicon plasmid pEc-050-TEM-30
Accession NZ_CP043228
Organism Escherichia coli strain Ec-050

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag FX998_RS23865 Protein ID WP_000970007.1
Coordinates 63350..63631 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag FX998_RS23870 Protein ID WP_000079941.1
Coordinates 63628..63897 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX998_RS23835 59977..60579 + 603 WP_000517695.1 hypothetical protein -
FX998_RS23840 60635..61129 + 495 WP_001459505.1 hypothetical protein -
FX998_RS23845 61129..61395 + 267 WP_000955263.1 hypothetical protein -
FX998_RS23855 61872..62345 - 474 WP_001334658.1 hypothetical protein -
FX998_RS23860 62462..63310 - 849 WP_001057996.1 3'-5' exonuclease -
FX998_RS23865 63350..63631 - 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FX998_RS23870 63628..63897 - 270 WP_000079941.1 hypothetical protein Antitoxin
FX998_RS25510 63952..64110 - 159 WP_000841008.1 hypothetical protein -
FX998_RS23885 64806..65837 - 1032 WP_000907873.1 replication initiation protein -
FX998_RS23900 66810..67073 + 264 WP_001324596.1 ash family protein -
FX998_RS23905 66991..67278 + 288 WP_000074849.1 conjugal transfer protein TraA -
FX998_RS23915 67720..68253 + 534 WP_001303319.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA1 / ant(3'')-Ia / qacE / sul1 / blaTEM-30 / floR / sul2 - 1..115935 115935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T138018 WP_000970007.1 NZ_CP043228:c63631-63350 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T138018 NZ_CP057221:c115282-115124 [Escherichia fergusonii]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT138018 WP_000079941.1 NZ_CP043228:c63897-63628 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT138018 NZ_CP043228:c63897-63628 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References