Detailed information of TA system TA137993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4547034..4547650
• Replicon: chromosome
• Accession: NZ_CP043226
• Organism: Enterobacter hormaechei strain PG20180049

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FYA22_RS21805
• Protein ID: WP_015569913.1
• Coordinates: 4547034..4547405 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: FYA22_RS21810
• Protein ID: WP_015569912.1
• Coordinates: 4547408..4547650 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA22_RS21790	4544534..4545436	+	903	WP_014072386.1	formate dehydrogenase subunit beta	-
FYA22_RS21795	4545433..4546068	+	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
FYA22_RS21800	4546065..4546994	+	930	WP_003861956.1	formate dehydrogenase accessory protein FdhE	-
FYA22_RS21805	4547034..4547405	-	372	WP_015569913.1	PIN domain-containing protein	Toxin
FYA22_RS21810	4547408..4547650	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
FYA22_RS21815	4547849..4548769	+	921	WP_047718170.1	alpha/beta hydrolase	-
FYA22_RS21820	4548778..4549719	-	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
FYA22_RS21825	4549764..4550201	-	438	WP_045348649.1	D-tyrosyl-tRNA(Tyr) deacylase	-
FYA22_RS21830	4550198..4551079	-	882	WP_003861949.1	virulence factor BrkB family protein	-
FYA22_RS21835	4551073..4551672	-	600	WP_003861947.1	glucose-1-phosphatase	-
FYA22_RS21840	4551791..4552591	-	801	WP_003861944.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13767.90 Da
• Isoelectric Point: 6.4882

>T137993 WP_015569913.1 NZ_CP043226:c4547405-4547034 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T137993 NZ_CP057215:c4014426-4014139 [Escherichia fergusonii]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGATGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGCATCGTGGTTATCCTGGTTGCGCATACCATCCGTTTCGAAAGTGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT137993 WP_015569912.1 NZ_CP043226:c4547650-4547408 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT137993 NZ_CP043226:c4547650-4547408 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3