Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3723212..3723869 Replicon chromosome
Accession NZ_CP043226
Organism Enterobacter hormaechei strain PG20180049

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag FYA22_RS17860 Protein ID WP_017382887.1
Coordinates 3723212..3723622 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag FYA22_RS17865 Protein ID WP_003863437.1
Coordinates 3723603..3723869 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA22_RS17840 3719210..3720943 - 1734 WP_047719217.1 single-stranded-DNA-specific exonuclease RecJ -
FYA22_RS17845 3720949..3721662 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FYA22_RS17850 3721691..3722587 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
FYA22_RS17855 3722689..3723210 + 522 WP_015571793.1 flavodoxin FldB -
FYA22_RS17860 3723212..3723622 - 411 WP_017382887.1 protein YgfX Toxin
FYA22_RS17865 3723603..3723869 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
FYA22_RS17870 3724164..3725144 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
FYA22_RS17875 3725256..3725915 - 660 WP_003863433.1 hemolysin III family protein -
FYA22_RS17880 3726182..3726913 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
FYA22_RS17885 3727030..3728463 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T137992 WP_017382887.1 NZ_CP043226:c3723622-3723212 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T137992 NZ_CP057215:c3661006-3660599 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT137992 WP_003863437.1 NZ_CP043226:c3723869-3723603 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT137992 NZ_CP043226:c3723869-3723603 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References