Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2309704..2310443 Replicon chromosome
Accession NZ_CP043226
Organism Enterobacter hormaechei strain PG20180049

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag FYA22_RS11065 Protein ID WP_003857133.1
Coordinates 2309704..2310189 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag FYA22_RS11070 Protein ID WP_003857131.1
Coordinates 2310177..2310443 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA22_RS11045 2305857..2306615 - 759 WP_047719553.1 trans-aconitate 2-methyltransferase -
FYA22_RS11050 2306700..2307284 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
FYA22_RS11055 2307371..2308129 + 759 WP_047719552.1 DeoR/GlpR family DNA-binding transcription regulator -
FYA22_RS11060 2308234..2309526 + 1293 WP_047719551.1 glycoside hydrolase -
FYA22_RS11065 2309704..2310189 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
FYA22_RS11070 2310177..2310443 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
FYA22_RS11075 2310507..2310641 - 135 Protein_2134 LysR family transcriptional regulator -
FYA22_RS11080 2310642..2311214 + 573 Protein_2135 MFS transporter -
FYA22_RS11085 2311236..2312231 - 996 WP_015570513.1 DUF2891 domain-containing protein -
FYA22_RS11090 2312241..2313227 - 987 WP_023296632.1 DUF979 domain-containing protein -
FYA22_RS11095 2313224..2313946 - 723 WP_003857121.1 DUF969 domain-containing protein -
FYA22_RS11100 2314171..2314719 + 549 WP_045142140.1 winged helix DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T137983 WP_003857133.1 NZ_CP043226:c2310189-2309704 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T137983 NZ_CP043226:c2310189-2309704 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT137983 WP_003857131.1 NZ_CP043226:c2310443-2310177 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT137983 NZ_CP057215:707791-707848 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References