Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1104449..1105069 Replicon chromosome
Accession NZ_CP043226
Organism Enterobacter hormaechei strain PG20180049

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FYA22_RS05220 Protein ID WP_015571250.1
Coordinates 1104449..1104667 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FYA22_RS05225 Protein ID WP_006809850.1
Coordinates 1104695..1105069 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA22_RS05190 1100461..1100721 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FYA22_RS05195 1100724..1100864 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FYA22_RS05200 1100861..1101571 - 711 WP_023296039.1 GNAT family N-acetyltransferase -
FYA22_RS05205 1101673..1103133 + 1461 WP_047718606.1 PLP-dependent aminotransferase family protein -
FYA22_RS05210 1103105..1103572 - 468 WP_023296041.1 hypothetical protein -
FYA22_RS05215 1103689..1104240 - 552 WP_045339381.1 maltose O-acetyltransferase -
FYA22_RS05220 1104449..1104667 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FYA22_RS05225 1104695..1105069 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FYA22_RS05230 1105580..1108726 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FYA22_RS05235 1108749..1109942 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T137981 WP_015571250.1 NZ_CP043226:c1104667-1104449 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T137981 NZ_CP057215:533746-534036 [Escherichia fergusonii]
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACAAAATTA
AGCTTCGCACACTGGGATATCGCCGGGTCTATCAGGTCAATGATAAAGAGTTGATCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT137981 WP_006809850.1 NZ_CP043226:c1105069-1104695 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT137981 NZ_CP057215:533514-533756 [Escherichia fergusonii]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAGGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References