Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2309691..2310430 Replicon chromosome
Accession NZ_CP043225
Organism Enterobacter hormaechei strain PG20180056

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag FYA23_RS11065 Protein ID WP_003857133.1
Coordinates 2309691..2310176 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag FYA23_RS11070 Protein ID WP_003857131.1
Coordinates 2310164..2310430 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA23_RS11045 2305844..2306602 - 759 WP_047719553.1 trans-aconitate 2-methyltransferase -
FYA23_RS11050 2306687..2307271 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
FYA23_RS11055 2307358..2308116 + 759 WP_047719552.1 DeoR/GlpR family DNA-binding transcription regulator -
FYA23_RS11060 2308221..2309513 + 1293 WP_047719551.1 glycoside hydrolase -
FYA23_RS11065 2309691..2310176 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
FYA23_RS11070 2310164..2310430 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
FYA23_RS11075 2310494..2310628 - 135 Protein_2134 LysR family transcriptional regulator -
FYA23_RS11080 2310629..2311201 + 573 Protein_2135 MFS transporter -
FYA23_RS11085 2311223..2312218 - 996 WP_015570513.1 DUF2891 domain-containing protein -
FYA23_RS11090 2312228..2313214 - 987 WP_023296632.1 DUF979 domain-containing protein -
FYA23_RS11095 2313211..2313933 - 723 WP_003857121.1 DUF969 domain-containing protein -
FYA23_RS11100 2314158..2314706 + 549 WP_045142140.1 winged helix DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T137969 WP_003857133.1 NZ_CP043225:c2310176-2309691 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T137969 NZ_CP057210:c4014381-4014094 [Escherichia fergusonii]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGATGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGCATCGTGGTTATCCTGGTTGCGCATACCATCCGTTTCGAAAGTGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT137969 WP_003857131.1 NZ_CP043225:c2310430-2310164 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT137969 NZ_CP043225:c2310430-2310164 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References