Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1104439..1105059 Replicon chromosome
Accession NZ_CP043225
Organism Enterobacter hormaechei strain PG20180056

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FYA23_RS05220 Protein ID WP_015571250.1
Coordinates 1104439..1104657 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FYA23_RS05225 Protein ID WP_006809850.1
Coordinates 1104685..1105059 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA23_RS05190 1100451..1100711 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FYA23_RS05195 1100714..1100854 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FYA23_RS05200 1100851..1101561 - 711 WP_023296039.1 GNAT family N-acetyltransferase -
FYA23_RS05205 1101663..1103123 + 1461 WP_047718606.1 PLP-dependent aminotransferase family protein -
FYA23_RS05210 1103095..1103562 - 468 WP_023296041.1 hypothetical protein -
FYA23_RS05215 1103679..1104230 - 552 WP_045339381.1 maltose O-acetyltransferase -
FYA23_RS05220 1104439..1104657 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FYA23_RS05225 1104685..1105059 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FYA23_RS05230 1105570..1108716 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FYA23_RS05235 1108739..1109932 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T137967 WP_015571250.1 NZ_CP043225:c1104657-1104439 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T137967 NZ_CP043225:c1104657-1104439 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT137967 WP_006809850.1 NZ_CP043225:c1105059-1104685 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT137967 NZ_CP057210:c3555199-3554906 [Escherichia fergusonii]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCTATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATTTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References