Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 55719..56241 Replicon plasmid pET6.3-IncI2
Accession NZ_CP043220
Organism Escherichia coli O80:H26 strain EC-107

Toxin (Protein)


Gene name relE Uniprot ID U9YLU1
Locus tag FYA02_RS26880 Protein ID WP_000638823.1
Coordinates 55719..56000 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y7J1
Locus tag FYA02_RS26885 Protein ID WP_000121741.1
Coordinates 55990..56241 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA02_RS26845 51868..52188 - 321 WP_000362080.1 VirB3 family type IV secretion system protein -
FYA02_RS26850 52259..52447 - 189 WP_050567133.1 hypothetical protein -
FYA02_RS26855 52549..53133 - 585 WP_001177113.1 lytic transglycosylase domain-containing protein -
FYA02_RS26860 53154..53552 - 399 WP_001153665.1 hypothetical protein -
FYA02_RS26865 53671..54108 - 438 WP_000539665.1 type IV pilus biogenesis protein PilM -
FYA02_RS26870 54114..55349 - 1236 WP_015059538.1 TcpQ domain-containing protein -
FYA02_RS26875 55352..55651 - 300 WP_000835764.1 IncN plasmid KikA protein -
FYA02_RS26880 55719..56000 - 282 WP_000638823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYA02_RS26885 55990..56241 - 252 WP_000121741.1 hypothetical protein Antitoxin
FYA02_RS26890 56341..56976 - 636 WP_015059536.1 hypothetical protein -
FYA02_RS26895 57024..57856 + 833 Protein_65 DNA primase -
FYA02_RS26900 57893..58129 - 237 WP_000750964.1 EexN family lipoprotein -
FYA02_RS26905 58133..58780 - 648 WP_000653673.1 conjugal transfer protein TrbJ -
FYA02_RS26910 58786..59772 - 987 WP_001028544.1 type IV secretion system protein -
FYA02_RS26915 59776..60033 - 258 WP_000739144.1 hypothetical protein -
FYA02_RS26920 60030..60332 - 303 WP_001360345.1 hypothetical protein -
FYA02_RS26930 60603..61049 - 447 WP_001243164.1 hypothetical protein -
FYA02_RS27175 61060..61230 - 171 WP_000550720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCMY-2 - 1..64997 64997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10945.79 Da        Isoelectric Point: 10.4997

>T137965 WP_000638823.1 NZ_CP043220:c56000-55719 [Escherichia coli O80:H26]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR

Download         Length: 282 bp

>T137965 NZ_CP057210:c2781391-2781236 [Escherichia fergusonii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.38 Da        Isoelectric Point: 3.9823

>AT137965 WP_000121741.1 NZ_CP043220:c56241-55990 [Escherichia coli O80:H26]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL

Download         Length: 252 bp

>AT137965 NZ_CP057210:2781403-2781461 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YLU1

Antitoxin

Source ID Structure
AlphaFold DB U9Y7J1

References