Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5066508..5066979 Replicon chromosome
Accession NZ_CP043217
Organism Escherichia coli O80:H26 strain EC-107

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag FYA02_RS25175 Protein ID WP_001303511.1
Coordinates 5066508..5066786 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag FYA02_RS25180 Protein ID WP_001302048.1
Coordinates 5066788..5066979 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA02_RS25140 5061844..5062113 - 270 WP_000003742.1 excisionase -
FYA02_RS25145 5062175..5064646 - 2472 WP_148880101.1 exonuclease -
FYA02_RS25150 5064739..5064930 - 192 WP_001090200.1 DUF1482 family protein -
FYA02_RS25155 5064927..5065115 - 189 WP_000449192.1 cell division inhibition protein DicB -
FYA02_RS25165 5065682..5065900 - 219 WP_001171933.1 hypothetical protein -
FYA02_RS25170 5066060..5066215 - 156 WP_000379593.1 DUF1391 family protein -
FYA02_RS25175 5066508..5066786 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYA02_RS25180 5066788..5066979 - 192 WP_001302048.1 hypothetical protein Antitoxin
FYA02_RS25185 5067000..5067371 - 372 WP_001169685.1 hypothetical protein -
FYA02_RS25190 5067469..5067771 + 303 WP_000172735.1 transcriptional regulator -
FYA02_RS25195 5067768..5068193 + 426 WP_000693841.1 Rha family transcriptional regulator -
FYA02_RS25200 5068265..5069335 + 1071 WP_148880102.1 phage replisome organizer -
FYA02_RS25205 5069342..5070088 + 747 WP_000788766.1 ATP-binding protein -
FYA02_RS25210 5070111..5070863 + 753 WP_089519137.1 DUF1627 domain-containing protein -
FYA02_RS25215 5070850..5071620 + 771 WP_148880103.1 ead/Ea22-like family protein -
FYA02_RS25220 5071622..5071831 + 210 WP_000951717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5061844..5074363 12519


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T137961 WP_001303511.1 NZ_CP043217:c5066786-5066508 [Escherichia coli O80:H26]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T137961 NZ_CP043217:c5066786-5066508 [Escherichia coli O80:H26]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT137961 WP_001302048.1 NZ_CP043217:c5066979-5066788 [Escherichia coli O80:H26]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT137961 NZ_CP043217:c5066979-5066788 [Escherichia coli O80:H26]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAGCGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References