Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3729541..3730339 | Replicon | chromosome |
| Accession | NZ_CP043217 | ||
| Organism | Escherichia coli O80:H26 strain EC-107 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0V7WHV8 |
| Locus tag | FYA02_RS18585 | Protein ID | WP_001506713.1 |
| Coordinates | 3729962..3730339 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1E5M1V9 |
| Locus tag | FYA02_RS18580 | Protein ID | WP_052913677.1 |
| Coordinates | 3729541..3729915 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYA02_RS18540 | 3725242..3725484 | + | 243 | Protein_3546 | IS3 family transposase | - |
| FYA02_RS18550 | 3726792..3727229 | + | 438 | Protein_3548 | DDE-type integrase/transposase/recombinase | - |
| FYA02_RS18555 | 3727239..3727790 | + | 552 | Protein_3549 | DUF945 domain-containing protein | - |
| FYA02_RS18560 | 3727790..3728035 | + | 246 | WP_001164975.1 | hypothetical protein | - |
| FYA02_RS18565 | 3728129..3728602 | + | 474 | WP_053879022.1 | antirestriction protein | - |
| FYA02_RS18570 | 3728618..3729094 | + | 477 | WP_001186726.1 | RadC family protein | - |
| FYA02_RS18575 | 3729157..3729378 | + | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
| FYA02_RS18580 | 3729541..3729915 | + | 375 | WP_052913677.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FYA02_RS18585 | 3729962..3730339 | + | 378 | WP_001506713.1 | TA system toxin CbtA family protein | Toxin |
| FYA02_RS18590 | 3730336..3730824 | + | 489 | WP_001470575.1 | hypothetical protein | - |
| FYA02_RS18595 | 3730836..3731033 | + | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| FYA02_RS27100 | 3731112..3731270 | + | 159 | WP_001467148.1 | hypothetical protein | - |
| FYA02_RS18620 | 3732315..3732965 | + | 651 | WP_001037966.1 | HNH endonuclease | - |
| FYA02_RS18625 | 3732973..3733953 | - | 981 | WP_001295601.1 | 9-O-acetyl-N-acetylneuraminic acid deacetylase | - |
| FYA02_RS18630 | 3734018..3735124 | - | 1107 | WP_001353974.1 | N-acetylneuraminate epimerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | eae / cesT / tir / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / sepZ/espZ / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG / fimB / fimE | 3694007..3738989 | 44982 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14178.26 Da Isoelectric Point: 7.8045
>T137955 WP_001506713.1 NZ_CP043217:3729962-3730339 [Escherichia coli O80:H26]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR
Download Length: 378 bp
>T137955 NZ_CP057150:c4548216-4547830 [Citrobacter sp. RHB35-C17]
ATGCAAAAGGGACCCGTGCTGTTCGATACCAATATCCTGATTGATTTATTCAGCGGGCACCAGGAAGCACAGCATGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCCTGGTTACCTGGATGGAAGTAATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACACGTGTGGCGTTGAGTGCGTTCAACATCATCGGCGTTTCACAGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATCATTCTGGCTACCGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTCGCGGGGATACCTGGCGTCATTACGCCTTATCAGTTGCAAGCCGGACGATAA
ATGCAAAAGGGACCCGTGCTGTTCGATACCAATATCCTGATTGATTTATTCAGCGGGCACCAGGAAGCACAGCATGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCCTGGTTACCTGGATGGAAGTAATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACACGTGTGGCGTTGAGTGCGTTCAACATCATCGGCGTTTCACAGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATCATTCTGGCTACCGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTCGCGGGGATACCTGGCGTCATTACGCCTTATCAGTTGCAAGCCGGACGATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13676.47 Da Isoelectric Point: 6.3139
>AT137955 WP_052913677.1 NZ_CP043217:3729541-3729915 [Escherichia coli O80:H26]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT137955 NZ_CP043217:3729541-3729915 [Escherichia coli O80:H26]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0V7WHV8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E5M1V9 |