Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3517060..3517892 | Replicon | chromosome |
| Accession | NZ_CP043217 | ||
| Organism | Escherichia coli O80:H26 strain EC-107 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | FYA02_RS17425 | Protein ID | WP_000854753.1 |
| Coordinates | 3517060..3517434 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7U9QGA8 |
| Locus tag | FYA02_RS17430 | Protein ID | WP_001280948.1 |
| Coordinates | 3517524..3517892 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYA02_RS17405 | 3513413..3514951 | - | 1539 | WP_001187177.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| FYA02_RS17410 | 3515700..3516269 | - | 570 | WP_001290252.1 | DUF4942 domain-containing protein | - |
| FYA02_RS17415 | 3516366..3516563 | - | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| FYA02_RS17420 | 3516575..3517063 | - | 489 | WP_000777552.1 | hypothetical protein | - |
| FYA02_RS17425 | 3517060..3517434 | - | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| FYA02_RS17430 | 3517524..3517892 | - | 369 | WP_001280948.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FYA02_RS17435 | 3518055..3518276 | - | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
| FYA02_RS17440 | 3518339..3518815 | - | 477 | WP_001186726.1 | RadC family protein | - |
| FYA02_RS17445 | 3518831..3519316 | - | 486 | WP_000849571.1 | antirestriction protein | - |
| FYA02_RS17450 | 3519371..3520189 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| FYA02_RS17460 | 3520289..3520522 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| FYA02_RS17465 | 3520601..3520987 | - | 387 | WP_122987528.1 | hypothetical protein | - |
| FYA02_RS17480 | 3522376..3522885 | + | 510 | Protein_3344 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T137954 WP_000854753.1 NZ_CP043217:c3517434-3517060 [Escherichia coli O80:H26]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T137954 NZ_CP057150:c4223564-4223088 [Citrobacter sp. RHB35-C17]
ATGGATTTTCCCACATGGCTGAACGGGTGGACGATCTACGCTCATCCCTGTTTTATCGATCAATACAACGCGCTGGTCGC
ACGTGTTGAAGACCTTAAGCACAGGTTTCCAGATCCCATTGTTTTCCAGAAGAAGAAAGAGACCAAGGTGCTGGCGCATT
TATTGAAATCCATTGCCAACATTACCCACGAACCCCGAGCTTCTGTTTACCGGCCTGGCGACAGTATAGGGAAAGCTTAT
ACAGACTGGTCGAGAGCGGAGTTTGGTGGAGGACGGTATCGCTTATTTTTCCGTTATAGTCTCGAGAGTAAGATCATTGT
CATCGCATGGGTGAATGATGAAGGGCCATTGCGCACCTACGGCAGCAAGACCGATGCCTATAAGATTTTCGGGAAAATGC
TCGATGAGGGGAATCCACCCGACGACTGGCTAAGTTTGCTTCAGGTTTGTCAAAACGACGGGAAGGAACATCTTTGA
ATGGATTTTCCCACATGGCTGAACGGGTGGACGATCTACGCTCATCCCTGTTTTATCGATCAATACAACGCGCTGGTCGC
ACGTGTTGAAGACCTTAAGCACAGGTTTCCAGATCCCATTGTTTTCCAGAAGAAGAAAGAGACCAAGGTGCTGGCGCATT
TATTGAAATCCATTGCCAACATTACCCACGAACCCCGAGCTTCTGTTTACCGGCCTGGCGACAGTATAGGGAAAGCTTAT
ACAGACTGGTCGAGAGCGGAGTTTGGTGGAGGACGGTATCGCTTATTTTTCCGTTATAGTCTCGAGAGTAAGATCATTGT
CATCGCATGGGTGAATGATGAAGGGCCATTGCGCACCTACGGCAGCAAGACCGATGCCTATAAGATTTTCGGGAAAATGC
TCGATGAGGGGAATCCACCCGACGACTGGCTAAGTTTGCTTCAGGTTTGTCAAAACGACGGGAAGGAACATCTTTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13609.50 Da Isoelectric Point: 7.3991
>AT137954 WP_001280948.1 NZ_CP043217:c3517892-3517524 [Escherichia coli O80:H26]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT137954 NZ_CP057150:c4223903-4223568 [Citrobacter sp. RHB35-C17]
ATGTTCGCCTATGTTCGATCTGAAGACATTGCCATTGAAGCGGATTCTAAATTGACGGAACGACATCAAACGACTATCCC
TGCGTCGATCAGGGACGCTTTACATCTTCGCAGTGGTGATCGTATTCATTACACATTGCTTTCCACGGGTGAAGTACTGC
TTTCAAAATACAGTGAAGCAACGGAGGACGGTGTGATGCGATCATTCCTGGACTTCTTATCACAGGATGTGGCGAATAAC
CCACAAACGCTGAAGAAGCTGGATTTATCCCGTGGCTATGAACTGGTTGATGGTATCGACGTCAATCTTGATGATGAAAT
CAGCGACGAAGACTGA
ATGTTCGCCTATGTTCGATCTGAAGACATTGCCATTGAAGCGGATTCTAAATTGACGGAACGACATCAAACGACTATCCC
TGCGTCGATCAGGGACGCTTTACATCTTCGCAGTGGTGATCGTATTCATTACACATTGCTTTCCACGGGTGAAGTACTGC
TTTCAAAATACAGTGAAGCAACGGAGGACGGTGTGATGCGATCATTCCTGGACTTCTTATCACAGGATGTGGCGAATAAC
CCACAAACGCTGAAGAAGCTGGATTTATCCCGTGGCTATGAACTGGTTGATGGTATCGACGTCAATCTTGATGATGAAAT
CAGCGACGAAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QGA8 |