Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1883043..1883878 Replicon chromosome
Accession NZ_CP043217
Organism Escherichia coli O80:H26 strain EC-107

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1V3VXN0
Locus tag FYA02_RS09590 Protein ID WP_000854801.1
Coordinates 1883501..1883878 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1V3VXQ4
Locus tag FYA02_RS09585 Protein ID WP_001360188.1
Coordinates 1883043..1883411 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA02_RS09560 1880158..1880976 + 819 WP_001234702.1 DUF945 domain-containing protein -
FYA02_RS09565 1881067..1881552 + 486 WP_000214418.1 antirestriction protein -
FYA02_RS09570 1881568..1882044 + 477 WP_001186725.1 RadC family protein -
FYA02_RS09575 1882113..1882334 + 222 WP_000692334.1 DUF987 domain-containing protein -
FYA02_RS09580 1882349..1882993 + 645 WP_000086744.1 hypothetical protein -
FYA02_RS09585 1883043..1883411 + 369 WP_001360188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FYA02_RS09590 1883501..1883878 + 378 WP_000854801.1 type IV toxin-antitoxin system toxin CbtA Toxin
FYA02_RS09595 1883875..1884363 + 489 WP_000761658.1 hypothetical protein -
FYA02_RS09600 1884375..1884572 + 198 WP_000839269.1 DUF957 domain-containing protein -
FYA02_RS27065 1884657..1885502 + 846 Protein_1844 DUF4942 domain-containing protein -
FYA02_RS09620 1886237..1888489 + 2253 Protein_1845 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13881.87 Da        Isoelectric Point: 7.3219

>T137947 WP_000854801.1 NZ_CP043217:1883501-1883878 [Escherichia coli O80:H26]
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T137947 NZ_CP057150:c91625-91284 [Citrobacter sp. RHB35-C17]
ATGAAACCTCTACCTGCAACAACTTCGCGGGCGGCGAAGCCTTGCCTGTCGCCCGTGGCAGTTTGGCAAATGCTGCTGAC
CCGACTGCTCGAAAAACACTATGGCCTGACGCTAAACGACACCCCGTTCAGTGATGAAACTGTGATTCAGGAAAACATTG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGTATCGACAGGAATGGATTT
AGCTGGCAGGAACAATCACCATATCTTCGGGCCGTCGATATCTTGCGGGCACGACAGGCCACCGGCTTGTTGCAACGAAA
CCGAAAACACGCTGCATTGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.27 Da        Isoelectric Point: 6.2044

>AT137947 WP_001360188.1 NZ_CP043217:1883043-1883411 [Escherichia coli O80:H26]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT137947 NZ_CP043217:1883043-1883411 [Escherichia coli O80:H26]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V3VXN0

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VXQ4

References