Detailed information of TA system TA137935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 125468..125946
• Replicon: chromosome
• Accession: NZ_CP043217
• Organism: Escherichia coli O80:H26 strain EC-107

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: FYA02_RS00690
• Protein ID: WP_089550521.1
• Coordinates: 125468..125755 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A7D8X397
• Locus tag: FYA02_RS00695
• Protein ID: WP_024207685.1
• Coordinates: 125755..125946 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA02_RS00660	120869..121117	-	249	WP_000113189.1	excisionase	-
FYA02_RS00665	121182..123653	-	2472	WP_148879990.1	exonuclease	-
FYA02_RS00670	123734..123937	-	204	WP_001090192.1	DUF1482 family protein	-
FYA02_RS00675	123940..124122	-	183	WP_148879991.1	cell division inhibition protein DicB	-
FYA02_RS00680	124654..125028	-	375	WP_000394557.1	hypothetical protein	-
FYA02_RS00685	125040..125192	-	153	WP_000379580.1	DUF1391 family protein	-
FYA02_RS00690	125468..125755	-	288	WP_089550521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYA02_RS00695	125755..125946	-	192	WP_024207685.1	hypothetical protein	Antitoxin
FYA02_RS00700	125974..126375	-	402	WP_001329851.1	helix-turn-helix domain-containing protein	-
FYA02_RS00705	126485..126757	+	273	WP_024207686.1	helix-turn-helix domain-containing protein	-
FYA02_RS00710	126741..127262	+	522	WP_089550520.1	hypothetical protein	-
FYA02_RS00715	127243..128208	+	966	WP_059239307.1	hypothetical protein	-
FYA02_RS00720	128215..128961	+	747	WP_000788766.1	ATP-binding protein	-
FYA02_RS00725	128984..129736	+	753	WP_148879992.1	DUF1627 domain-containing protein	-
FYA02_RS00730	129723..130424	+	702	WP_059239302.1	ead/Ea22-like family protein	-
FYA02_RS00735	130421..130711	+	291	WP_069723346.1	DUF4752 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	110029..164032	54003

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10889.79 Da
• Isoelectric Point: 10.1360

>T137935 WP_089550521.1 NZ_CP043217:c125755-125468 [Escherichia coli O80:H26]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVAASSIE
IANIVHARRQFPFSI

Nucleotide

• Length: 288 bp

>T137935 NZ_CP057147:c790851-790471 [Citrobacter sp. RHB35-C21]
ATGCAGACCTTATCCGCCATCCCGACGCGGAAGGCACCGTCACACCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGAAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7017.77 Da
• Isoelectric Point: 4.0270

>AT137935 WP_024207685.1 NZ_CP043217:c125946-125755 [Escherichia coli O80:H26]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEIENLIAQIAVTNRSE

Nucleotide

• Length: 192 bp

>AT137935 NZ_CP057147:c791274-790909 [Citrobacter sp. RHB35-C21]
TTGTCGAATCAACTACCTCCAGTAAACCATGATGTCTCTGAGCCCTGGTGGGGGCTGAAACCGGGCATCACTCCGTGTTT
TGGCGCACGACTGGTACAGGAAGGCAACCGCCTGCATTATCTGGCTGATCGGGCCAGTATCGCCGGTGTGTTCAGCGATG
CGGATTTACGCCATCTCGATCAGGCATTTCCGGCACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCCGCCATCAGCACTGTGTCACGTTATATGCAAAAGGGCTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATGTATCCGACACCAGACAACAGCATAACCCGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7D8X397