Detailed information of TA system TA137934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 33131..33653
• Replicon: plasmid pET8.2-IncX1
• Accession: NZ_CP043216
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain SL-312

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: FYA03_RS24495
• Protein ID: WP_000220560.1
• Coordinates: 33372..33653 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: FYA03_RS24490
• Protein ID: WP_000121743.1
• Coordinates: 33131..33382 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA03_RS24460	28802..29083	+	282	WP_001185482.1	hypothetical protein	-
FYA03_RS24465	29108..30085	+	978	WP_001269910.1	hypothetical protein	-
FYA03_RS24470	30082..30507	-	426	WP_000202944.1	hypothetical protein	-
FYA03_RS24475	30575..31021	-	447	WP_001074386.1	hypothetical protein	-
FYA03_RS24480	31061..31897	-	837	WP_001050931.1	replication initiation protein	-
FYA03_RS24490	33131..33382	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
FYA03_RS24495	33372..33653	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYA03_RS24500	33799..34122	+	324	WP_001181903.1	hypothetical protein	-
FYA03_RS24505	34167..34412	+	246	WP_000356547.1	hypothetical protein	-
FYA03_RS24510	34402..34617	+	216	WP_001180116.1	hypothetical protein	-
FYA03_RS24515	34710..35039	+	330	WP_000866646.1	hypothetical protein	-
FYA03_RS24520	35082..35261	+	180	WP_000439078.1	hypothetical protein	-
FYA03_RS24525	35283..35480	+	198	WP_001675595.1	hypothetical protein	-
FYA03_RS24530	35493..35765	+	273	WP_000160399.1	hypothetical protein	-
FYA03_RS24660	36022..36096	+	75	Protein_42	DNA distortion polypeptide 3	-
FYA03_RS24535	36091..36636	+	546	WP_000757693.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37697	37697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T137934 WP_000220560.1 NZ_CP043216:33372-33653 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T137934 NZ_CP043216:33372-33653 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT137934 WP_000121743.1 NZ_CP043216:33131-33382 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT137934 NZ_CP043216:33131-33382 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301