Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 3233777..3235214 | Replicon | chromosome |
| Accession | NZ_CP043213 | ||
| Organism | Escherichia coli O16:H48 strain CV601gfp | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | FYA04_RS15855 | Protein ID | WP_000155570.1 |
| Coordinates | 3233777..3234850 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | FYA04_RS15860 | Protein ID | WP_000461704.1 |
| Coordinates | 3234843..3235214 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYA04_RS15840 | 3229210..3231399 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| FYA04_RS15845 | 3231396..3233012 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| FYA04_RS15850 | 3233372..3233635 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| FYA04_RS15855 | 3233777..3234850 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| FYA04_RS15860 | 3234843..3235214 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| FYA04_RS15865 | 3235569..3236432 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| FYA04_RS15870 | 3236524..3237345 | + | 822 | WP_000197391.1 | DUF945 domain-containing protein | - |
| FYA04_RS15875 | 3237562..3238263 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| FYA04_RS15880 | 3238304..3238540 | + | 237 | WP_001144029.1 | hypothetical protein | - |
| FYA04_RS15885 | 3238540..3238983 | + | 444 | WP_000824222.1 | hypothetical protein | - |
| FYA04_RS15890 | 3239007..3239474 | + | 468 | WP_000702495.1 | hypothetical protein | - |
| FYA04_RS15895 | 3239699..3240013 | - | 315 | WP_000065803.1 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T137924 WP_000155570.1 NZ_CP043213:3233777-3234850 [Escherichia coli O16:H48]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
>T137924 NZ_CP057136:1037163-1037531 [Citrobacter freundii]
ATGAAAACTCTACCTGCTACAATATCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGTCCCTGAACGATACGCCGTTCTGTGATCAATCCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCTGTTAACTTTCTGGTAGAAAAGAATGAGTTAATTCGTATCGATCGCAATGGATTT
ACCTTACAGGAACGAACGCCATATTTGACGGTGACAGATATCCTTCATGCCAAGAGAGCATGCGGATTAATGAACGGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA
ATGAAAACTCTACCTGCTACAATATCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGTCCCTGAACGATACGCCGTTCTGTGATCAATCCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCTGTTAACTTTCTGGTAGAAAAGAATGAGTTAATTCGTATCGATCGCAATGGATTT
ACCTTACAGGAACGAACGCCATATTTGACGGTGACAGATATCCTTCATGCCAAGAGAGCATGCGGATTAATGAACGGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT137924 WP_000461704.1 NZ_CP043213:3234843-3235214 [Escherichia coli O16:H48]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
>AT137924 NZ_CP043213:3234843-3235214 [Escherichia coli O16:H48]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|