137892

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 349332..350146 Replicon chromosome
Accession NZ_CP043213
Organism Escherichia coli O16:H48 strain CV601gfp

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag FYA04_RS01645 Protein ID WP_001054376.1
Coordinates 349889..350146 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag FYA04_RS01640 Protein ID WP_001309181.1
Coordinates 349332..349877 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA04_RS01615 345023..346336 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
FYA04_RS01620 346348..346626 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
FYA04_RS01625 346623..347744 - 1122 WP_000010829.1 M42 family metallopeptidase -
FYA04_RS23030 347989..348105 - 117 Protein_317 VOC family protein -
FYA04_RS01630 348143..348361 - 219 Protein_318 hypothetical protein -
FYA04_RS01635 348530..349276 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
FYA04_RS01640 349332..349877 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
FYA04_RS01645 349889..350146 - 258 WP_001054376.1 hypothetical protein Toxin
FYA04_RS01650 350523..350768 - 246 Protein_322 GNAT family N-acetyltransferase -
FYA04_RS01655 350884..352124 + 1241 Protein_323 helicase YjhR -
FYA04_RS01660 352707..353687 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
FYA04_RS01665 353752..354858 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T137892 WP_001054376.1 NZ_CP043213:c350146-349889 [Escherichia coli O16:H48]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T137892 NZ_CP043213:c350146-349889 [Escherichia coli O16:H48]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT137892 WP_001309181.1 NZ_CP043213:c349877-349332 [Escherichia coli O16:H48]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT137892 NZ_CP057104:654375-654608 [Escherichia fergusonii]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References