Detailed information of TA system TA137885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4291395..4292209
• Replicon: chromosome
• Accession: NZ_CP043211
• Organism: Escherichia coli O16:H48 strain PG20180050

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: FYA05_RS20970
• Protein ID: WP_001054376.1
• Coordinates: 4291395..4291652 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: FYA05_RS20975
• Protein ID: WP_001309181.1
• Coordinates: 4291664..4292209 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA05_RS20950	4286683..4287789	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
FYA05_RS20955	4287854..4288834	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
FYA05_RS20960	4289417..4290657	-	1241	Protein_4073	helicase YjhR	-
FYA05_RS20965	4290773..4291018	+	246	Protein_4074	GNAT family N-acetyltransferase	-
FYA05_RS20970	4291395..4291652	+	258	WP_001054376.1	hypothetical protein	Toxin
FYA05_RS20975	4291664..4292209	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
FYA05_RS20980	4292265..4293011	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
FYA05_RS20985	4293180..4293398	+	219	Protein_4078	hypothetical protein	-
FYA05_RS23220	4293436..4293552	+	117	Protein_4079	VOC family protein	-
FYA05_RS20990	4293797..4294918	+	1122	WP_000010829.1	M42 family metallopeptidase	-
FYA05_RS20995	4294915..4295193	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
FYA05_RS21000	4295205..4296518	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4282646..4300433	17787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T137885 WP_001054376.1 NZ_CP043211:4291395-4291652 [Escherichia coli O16:H48]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T137885 NZ_CP043211:4291395-4291652 [Escherichia coli O16:H48]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT137885 WP_001309181.1 NZ_CP043211:4291664-4292209 [Escherichia coli O16:H48]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT137885 NZ_CP043211:4291664-4292209 [Escherichia coli O16:H48]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8