Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4091424..4092019 Replicon chromosome
Accession NZ_CP043205
Organism Escherichia coli O16:H48 strain PG20180054

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag FYA08_RS20060 Protein ID WP_000239577.1
Coordinates 4091424..4091774 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag FYA08_RS20065 Protein ID WP_001223208.1
Coordinates 4091768..4092019 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA08_RS20040 4086870..4087892 - 1023 WP_001313531.1 ABC transporter permease -
FYA08_RS20045 4087906..4089408 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
FYA08_RS20050 4089548..4090504 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FYA08_RS20055 4090814..4091344 + 531 WP_000055075.1 inorganic diphosphatase -
FYA08_RS20060 4091424..4091774 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
FYA08_RS20065 4091768..4092019 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FYA08_RS20070 4092231..4092572 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FYA08_RS20075 4092575..4096354 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T137787 WP_000239577.1 NZ_CP043205:c4091774-4091424 [Escherichia coli O16:H48]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T137787 NZ_CP043205:c4091774-4091424 [Escherichia coli O16:H48]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT137787 WP_001223208.1 NZ_CP043205:c4092019-4091768 [Escherichia coli O16:H48]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT137787 NZ_CP056967:c4271850-4271608 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGATAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGATA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References