Detailed information of TA system TA137720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4006239..4007053
• Replicon: chromosome
• Accession: NZ_CP043201
• Organism: Escherichia coli O16:H48 strain PG20180059

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: FYA10_RS19630
• Protein ID: WP_001054376.1
• Coordinates: 4006239..4006496 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: FYA10_RS19635
• Protein ID: WP_001309181.1
• Coordinates: 4006508..4007053 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA10_RS19610	4001527..4002633	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
FYA10_RS19615	4002698..4003678	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
FYA10_RS19620	4004261..4005501	-	1241	Protein_3826	helicase YjhR	-
FYA10_RS19625	4005617..4005862	+	246	Protein_3827	GNAT family N-acetyltransferase	-
FYA10_RS19630	4006239..4006496	+	258	WP_001054376.1	hypothetical protein	Toxin
FYA10_RS19635	4006508..4007053	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
FYA10_RS19640	4007109..4007855	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
FYA10_RS19645	4008024..4008242	+	219	Protein_3831	hypothetical protein	-
FYA10_RS23405	4008280..4008396	+	117	Protein_3832	VOC family protein	-
FYA10_RS19650	4008641..4009762	+	1122	WP_000010829.1	M42 family metallopeptidase	-
FYA10_RS19655	4009759..4010037	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
FYA10_RS19660	4010049..4011362	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	3997490..4015277	17787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T137720 WP_001054376.1 NZ_CP043201:4006239-4006496 [Escherichia coli O16:H48]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T137720 NZ_CP056910:4121935-4122276 [Citrobacter freundii]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGGATCTCGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCGCCTTATCTTCAGGCTGTCGATATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCAGCAAAG
CCGTAGCAACGTAGTACGATGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT137720 WP_001309181.1 NZ_CP043201:4006508-4007053 [Escherichia coli O16:H48]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT137720 NZ_CP056910:4121597-4121914 [Citrobacter freundii]
ATGACCCACATCAACTGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAAGTCAGCCCCCAACATGCCCACTGCGTCATCATGTACCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGTTACGTGTACATCGCCATTTATCCCACCCAGCGCTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8