Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
Location | 6861..7354 | Replicon | plasmid pPG20180060.1-IncI2 |
Accession | NZ_CP043200 | ||
Organism | Escherichia coli O16:H48 strain PG20180060 |
Toxin (Protein)
Gene name | TsxA | Uniprot ID | U9Y9W8 |
Locus tag | FYA11_RS22860 | Protein ID | WP_001230709.1 |
Coordinates | 6861..7115 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | TsxB | Uniprot ID | U9Y4R8 |
Locus tag | FYA11_RS22865 | Protein ID | WP_000151456.1 |
Coordinates | 7112..7354 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FYA11_RS22820 | 2433..2594 | + | 162 | WP_001366886.1 | type I toxin-antitoxin system Hok family toxin | - |
FYA11_RS22825 | 2744..3340 | + | 597 | WP_000125165.1 | hypothetical protein | - |
FYA11_RS23365 | 3358..3642 | - | 285 | WP_001162371.1 | hypothetical protein | - |
FYA11_RS22835 | 3716..4381 | - | 666 | WP_000532148.1 | P-loop NTPase | - |
FYA11_RS22845 | 4970..5299 | + | 330 | WP_000855119.1 | hypothetical protein | - |
FYA11_RS22850 | 5703..6218 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
FYA11_RS22855 | 6322..6864 | + | 543 | WP_001083904.1 | hypothetical protein | - |
FYA11_RS22860 | 6861..7115 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
FYA11_RS22865 | 7112..7354 | + | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
FYA11_RS22870 | 7925..8218 | + | 294 | WP_000673428.1 | hypothetical protein | - |
FYA11_RS22875 | 8628..8810 | - | 183 | WP_024135751.1 | hypothetical protein | - |
FYA11_RS22880 | 9368..9550 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
FYA11_RS22885 | 9575..10012 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
FYA11_RS22890 | 10143..10463 | - | 321 | WP_001401701.1 | hypothetical protein | - |
FYA11_RS22900 | 10797..10975 | - | 179 | Protein_15 | hypothetical protein | - |
FYA11_RS22905 | 10977..11180 | - | 204 | WP_000224735.1 | hypothetical protein | - |
FYA11_RS22910 | 11186..11635 | - | 450 | WP_000206700.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | blaCMY-2 | - | 1..64997 | 64997 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T137690 WP_001230709.1 NZ_CP043200:6861-7115 [Escherichia coli O16:H48]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T137690 NZ_CP056899:c3085608-3085255 [Citrobacter sp. RHBSTW-00017]
GTGTGGACGATTAAAACAACGGATATGTTTGATCACTGGTTTTCCTCGCTCAATGATATCGATCGGGCCAGCGTGCTTGC
AGCGCTGTTGGTCTTGCGGGAAAAGGGGCCAGGTTTGTCCAGACCTTATGCCGATACGCTTAGAGGCTCCCGCTTTAGCA
ACATGAAAGAGTTGCGCATTCAGAGCCGGGGCGATCCGATACGGGCATTTTTCGCTTTTGATCCAGCCCGTACCGGCATT
GTACTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGATCCCGGTTGCAGATCGGGAATTCAC
GAACTGGCTGAACACAATAAAAGAGAAGGAGTAA
GTGTGGACGATTAAAACAACGGATATGTTTGATCACTGGTTTTCCTCGCTCAATGATATCGATCGGGCCAGCGTGCTTGC
AGCGCTGTTGGTCTTGCGGGAAAAGGGGCCAGGTTTGTCCAGACCTTATGCCGATACGCTTAGAGGCTCCCGCTTTAGCA
ACATGAAAGAGTTGCGCATTCAGAGCCGGGGCGATCCGATACGGGCATTTTTCGCTTTTGATCCAGCCCGTACCGGCATT
GTACTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGATCCCGGTTGCAGATCGGGAATTCAC
GAACTGGCTGAACACAATAAAAGAGAAGGAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT137690 WP_000151456.1 NZ_CP043200:7112-7354 [Escherichia coli O16:H48]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT137690 NZ_CP043200:7112-7354 [Escherichia coli O16:H48]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G9H8F0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G9GNF5 |