137582

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4187395..4187892 Replicon chromosome
Accession NZ_CP043193
Organism Escherichia coli O16:H48 strain PG20180063

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag FYA14_RS20560 Protein ID WP_001173343.1
Coordinates 4187395..4187568 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag FYA14_RS20565 Protein ID WP_000398619.1
Coordinates 4187596..4187892 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA14_RS20550 4184065..4185522 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
FYA14_RS20555 4185759..4187276 + 1518 WP_001295074.1 lysine--tRNA ligase -
FYA14_RS20560 4187395..4187568 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
FYA14_RS20565 4187596..4187892 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
FYA14_RS20570 4188119..4188391 - 273 WP_000405651.1 N-acetyltransferase -
FYA14_RS20575 4188403..4188633 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
FYA14_RS20580 4188814..4190445 + 1632 WP_001216477.1 sensor histidine kinase -
FYA14_RS20585 4190442..4191161 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T137582 WP_001173343.1 NZ_CP043193:c4187568-4187395 [Escherichia coli O16:H48]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T137582 NZ_CP056834:2061187-2061290 [Citrobacter sp. RHBSTW-00127]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT137582 WP_000398619.1 NZ_CP043193:c4187892-4187596 [Escherichia coli O16:H48]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT137582 NZ_CP056834:c2061295-2061152 [Citrobacter sp. RHBSTW-00127]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References